> For the complete documentation index, see [llms.txt](https://help.connected.illumina.com/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://help.connected.illumina.com/annotation/v4.0/data-sources/data-catalogs.md).

# Data Catalogs

A **data catalog** is a curated, versioned bundle of annotation data sources (clinical databases, population frequencies, conservation scores, gene models, and more) that DRAGEN Annotation uses at runtime. Each catalog is scoped to a reference assembly (`GRCh37`, `GRCh38`) and split into **categories** such as `basic`, `germline-tagging`, `methylation`, `premium`, and `tmb`. Categories flagged as **premium** require Professional credentials; the rest are available with a free MyIllumina API Key.

The tables below show exactly which data sources and versions each catalog ships with. Use this page to decide, **before** running `Annotator setup` or `Annotator download`, which catalog and which categories you need. During `setup`, you will pick a catalog by its `Catalog ID` (e.g. `20260501`) and one or more assemblies; `setup` then generates the matching run configs (one per assembly + category) that `download` consumes. See [Command Line Parameters](/annotation/v4.0/software-functionality/command-line-parameters.md) for the full `setup` and `download` workflows.

This page is auto-generated from the annotation metadata registry.

* Registry schema version: `1.0.0`
* Registry generated at: `2026-07-22T13:10:54Z`

## Catalogs Overview

| Catalog ID | Name       | Release Date |
| ---------- | ---------- | ------------ |
| 20260501   | May 2026   | 2026-05-01   |
| dragen-4.6 | Dragen 4.6 | 2026-08-01   |
| dragen-4.5 | Dragen 4.5 | 2026-01-01   |

## Assembly: GRCh37

### Catalog: May 2026 (`20260501`) — Released 2026-05-01

Categories in this catalog:

| Category         | Premium | Run Config                            |
| ---------------- | ------- | ------------------------------------- |
| basic            | No      | GRCh37.20260501.basic.json            |
| germline-tagging | No      | GRCh37.20260501.germline-tagging.json |
| methylation      | No      | GRCh37.20260501.methylation.json      |
| premium          | Yes     | GRCh37.20260501.premium.json          |
| tmb              | Yes     | GRCh37.20260501.tmb.json              |

#### Category: basic

Run config: `GRCh37.20260501.basic.json`

| Source           | Data Type            | Version                        |
| ---------------- | -------------------- | ------------------------------ |
| ABRaOM           | SmallVariant         | SABE\_609\_exomes              |
| DANN             | Score                | 20200205                       |
| DECIPHER         | StructuralVariant    | 201509                         |
| Ensembl          | GeneModels           | 110                            |
| FusionCatcher    | GeneFusion           | 1.33                           |
| GME              | SmallVariant         | 20160618                       |
| GenomeAssembly   | GenomeAssembly       | GRCh37.p13                     |
| Gerp             | Score                | 20110522                       |
| HGNC             | GeneModels           | 20260209                       |
| MultiZ100Way     | Protein              | 20150427                       |
| REVEL            | SmallVariant         | 20200205                       |
| RefSeq           | GeneModels           | GCF\_000001405.25-RS\_2024\_09 |
| TOPMed           | SmallVariant         | freeze\_5                      |
| UcscCpgIsland    | MethylationRegion    | 20200322                       |
| alphaMissense    | SmallVariant         | 1.0                            |
| clingen          | Gene                 | 20260505                       |
| clingen          | StructuralVariant    | 20260505                       |
| clingen (legacy) | StructuralVariant    | 20160414                       |
| clinvar          | SmallVariant         | 20260328                       |
| clinvar          | StructuralVariant    | 20260328                       |
| clinvar-preview  | SmallVariant         | 20250601                       |
| clinvar-preview  | StructuralVariant    | 20250601                       |
| dbSNP            | SmallVariant         | 157                            |
| globalAllele     | SmallVariant         | 151                            |
| gnomad           | Gene                 | 4.1.1                          |
| gnomad           | LowComplexityRegions | 2.1                            |
| gnomad           | SmallVariant         | 4.1                            |
| gnomad           | StructuralVariant    | 2.1                            |
| gnomad-exome     | SmallVariant         | 4.1                            |
| mitomap          | SmallVariant         | 20200819                       |
| mitomap          | StructuralVariant    | 20200819                       |
| oneKg            | RefMinor             | Phase 3 v5a                    |
| oneKg            | SmallVariant         | Phase 3 v5a                    |
| oneKg            | StructuralVariant    | Phase 3 v5a                    |
| phylopScore      | ConservationScore    | hg19                           |

#### Category: germline-tagging

Run config: `GRCh37.20260501.germline-tagging.json`

| Source         | Data Type      | Version                    |
| -------------- | -------------- | -------------------------- |
| ABRaOM         | SmallVariant   | SABE\_609\_exomes\_trimmed |
| GenomeAssembly | GenomeAssembly | GRCh37.p13                 |
| gnomad         | SmallVariant   | 2.1\_trimmed               |
| oneKg          | SmallVariant   | Phase 3 v5a\_trimmed       |

#### Category: methylation

Run config: `GRCh37.20260501.methylation.json`

| Source         | Data Type         | Version                        |
| -------------- | ----------------- | ------------------------------ |
| Ensembl        | GeneModels        | 110                            |
| GenomeAssembly | GenomeAssembly    | GRCh37.p13                     |
| HGNC           | GeneModels        | 20260209                       |
| RefSeq         | GeneModels        | GCF\_000001405.25-RS\_2024\_09 |
| UcscCpgIsland  | MethylationRegion | 20200322                       |

#### Category: premium (premium)

Run config: `GRCh37.20260501.premium.json`

| Source           | Data Type            | Version                        |
| ---------------- | -------------------- | ------------------------------ |
| ABRaOM           | SmallVariant         | SABE\_609\_exomes              |
| DANN             | Score                | 20200205                       |
| DECIPHER         | StructuralVariant    | 201509                         |
| Ensembl          | GeneModels           | 110                            |
| FusionCatcher    | GeneFusion           | 1.33                           |
| GME              | SmallVariant         | 20160618                       |
| GenomeAssembly   | GenomeAssembly       | GRCh37.p13                     |
| Gerp             | Score                | 20110522                       |
| HGNC             | GeneModels           | 20260209                       |
| MultiZ100Way     | Protein              | 20150427                       |
| PrimateAI        | SmallVariant         | 0.2                            |
| PromoterAI       | SmallVariant         | 1.1                            |
| REVEL            | SmallVariant         | 20200205                       |
| RefSeq           | GeneModels           | GCF\_000001405.25-RS\_2024\_09 |
| TOPMed           | SmallVariant         | freeze\_5                      |
| UcscCpgIsland    | MethylationRegion    | 20200322                       |
| alphaMissense    | SmallVariant         | 1.0                            |
| clingen          | Gene                 | 20260505                       |
| clingen          | StructuralVariant    | 20260505                       |
| clingen (legacy) | StructuralVariant    | 20160414                       |
| clinvar          | SmallVariant         | 20260328                       |
| clinvar          | StructuralVariant    | 20260328                       |
| clinvar-preview  | SmallVariant         | 20250601                       |
| clinvar-preview  | StructuralVariant    | 20250601                       |
| cosmic           | Gene                 | 103                            |
| cosmic           | GeneFusion           | 103                            |
| cosmic           | SmallVariant         | 103                            |
| dbSNP            | SmallVariant         | 157                            |
| globalAllele     | SmallVariant         | 151                            |
| gnomad           | Gene                 | 4.1.1                          |
| gnomad           | LowComplexityRegions | 2.1                            |
| gnomad           | SmallVariant         | 4.1                            |
| gnomad           | StructuralVariant    | 2.1                            |
| gnomad-exome     | SmallVariant         | 4.1                            |
| mitomap          | SmallVariant         | 20200819                       |
| mitomap          | StructuralVariant    | 20200819                       |
| omim             | Gene                 | 20260505                       |
| oneKg            | RefMinor             | Phase 3 v5a                    |
| oneKg            | SmallVariant         | Phase 3 v5a                    |
| oneKg            | StructuralVariant    | Phase 3 v5a                    |
| phylopScore      | ConservationScore    | hg19                           |
| primateAI-3D     | SmallVariant         | 1.0                            |
| spliceAI         | SmallVariant         | 1.3                            |

#### Category: tmb (premium)

Run config: `GRCh37.20260501.tmb.json`

| Source         | Data Type      | Version                    |
| -------------- | -------------- | -------------------------- |
| ABRaOM         | SmallVariant   | SABE\_609\_exomes\_trimmed |
| Ensembl        | GeneModels     | 110                        |
| GenomeAssembly | GenomeAssembly | GRCh37.p13                 |
| HGNC           | GeneModels     | 20240603                   |
| RefSeq         | GeneModels     | 105.20220307               |
| clinvar        | SmallVariant   | 20250601\_trimmed          |
| cosmic         | SmallVariant   | 102\_trimmed               |
| gnomad         | SmallVariant   | 2.1\_trimmed               |
| oneKg          | SmallVariant   | Phase 3 v5a\_trimmed       |

### Catalog: Dragen 4.6 (`dragen-4.6`) — Released 2026-08-01

Categories in this catalog:

| Category         | Premium | Run Config                               |
| ---------------- | ------- | ---------------------------------------- |
| germline-tagging | No      | GRCh37.DRAGEN\_4.6.germline-tagging.json |
| methylation      | No      | GRCh37.DRAGEN\_4.6.methylation.json      |
| premium          | Yes     | GRCh37.DRAGEN\_4.6.premium.json          |
| tmb              | Yes     | GRCh37.DRAGEN\_4.6.tmb.json              |

#### Category: germline-tagging

Run config: `GRCh37.DRAGEN_4.6.germline-tagging.json`

| Source         | Data Type      | Version                    |
| -------------- | -------------- | -------------------------- |
| ABRaOM         | SmallVariant   | SABE\_609\_exomes\_trimmed |
| GenomeAssembly | GenomeAssembly | GRCh37.p13                 |
| gnomad         | SmallVariant   | 2.1\_trimmed               |
| oneKg          | SmallVariant   | Phase 3 v5a\_trimmed       |

#### Category: methylation

Run config: `GRCh37.DRAGEN_4.6.methylation.json`

| Source         | Data Type         | Version      |
| -------------- | ----------------- | ------------ |
| Ensembl        | GeneModels        | 110          |
| GenomeAssembly | GenomeAssembly    | GRCh37.p13   |
| HGNC           | GeneModels        | 20260209     |
| RefSeq         | GeneModels        | 105.20220307 |
| UcscCpgIsland  | MethylationRegion | 20200322     |

#### Category: premium (premium)

Run config: `GRCh37.DRAGEN_4.6.premium.json`

| Source           | Data Type            | Version           |
| ---------------- | -------------------- | ----------------- |
| ABRaOM           | SmallVariant         | SABE\_609\_exomes |
| DANN             | Score                | 20200205          |
| DECIPHER         | StructuralVariant    | 201509            |
| Ensembl          | GeneModels           | 110               |
| FusionCatcher    | GeneFusion           | 1.33              |
| GME              | SmallVariant         | 20160618          |
| GenomeAssembly   | GenomeAssembly       | GRCh37.p13        |
| Gerp             | Score                | 20110522          |
| HGNC             | GeneModels           | 20260209          |
| MultiZ100Way     | Protein              | 20150427          |
| PrimateAI        | SmallVariant         | 0.2               |
| PromoterAI       | SmallVariant         | 1.1               |
| REVEL            | SmallVariant         | 20200205          |
| RefSeq           | GeneModels           | 105.20220307      |
| TOPMed           | SmallVariant         | freeze\_5         |
| UcscCpgIsland    | MethylationRegion    | 20200322          |
| alphaMissense    | SmallVariant         | 1.0               |
| clingen          | Gene                 | 20260505          |
| clingen          | StructuralVariant    | 20260505          |
| clingen (legacy) | StructuralVariant    | 20160414          |
| clinvar          | SmallVariant         | 20260328          |
| clinvar          | StructuralVariant    | 20260328          |
| clinvar-preview  | SmallVariant         | 20250601          |
| clinvar-preview  | StructuralVariant    | 20250601          |
| cosmic           | Gene                 | 103               |
| cosmic           | GeneFusion           | 103               |
| cosmic           | SmallVariant         | 103               |
| dbSNP            | SmallVariant         | 157               |
| globalAllele     | SmallVariant         | 151               |
| gnomad           | Gene                 | 4.1.1             |
| gnomad           | LowComplexityRegions | 2.1               |
| gnomad           | SmallVariant         | 4.1               |
| gnomad           | StructuralVariant    | 2.1               |
| gnomad-exome     | SmallVariant         | 4.1               |
| mitomap          | SmallVariant         | 20200819          |
| mitomap          | StructuralVariant    | 20200819          |
| omim             | Gene                 | 20260505          |
| oneKg            | RefMinor             | Phase 3 v5a       |
| oneKg            | SmallVariant         | Phase 3 v5a       |
| oneKg            | StructuralVariant    | Phase 3 v5a       |
| phylopScore      | ConservationScore    | hg19              |
| primateAI-3D     | SmallVariant         | 1.0               |
| spliceAI         | SmallVariant         | 1.3               |

#### Category: tmb (premium)

Run config: `GRCh37.DRAGEN_4.6.tmb.json`

| Source         | Data Type      | Version                    |
| -------------- | -------------- | -------------------------- |
| ABRaOM         | SmallVariant   | SABE\_609\_exomes\_trimmed |
| Ensembl        | GeneModels     | 110                        |
| GenomeAssembly | GenomeAssembly | GRCh37.p13                 |
| HGNC           | GeneModels     | 20240603                   |
| RefSeq         | GeneModels     | 105.20220307               |
| clinvar        | SmallVariant   | 20250601\_trimmed          |
| cosmic         | SmallVariant   | 102\_trimmed               |
| gnomad         | SmallVariant   | 2.1\_trimmed               |
| oneKg          | SmallVariant   | Phase 3 v5a\_trimmed       |

### Catalog: Dragen 4.5 (`dragen-4.5`) — Released 2026-01-01

Categories in this catalog:

| Category         | Premium | Run Config                               |
| ---------------- | ------- | ---------------------------------------- |
| germline-tagging | No      | GRCh37.DRAGEN\_4.5.germline-tagging.json |
| methylation      | No      | GRCh37.DRAGEN\_4.5.methylation.json      |
| premium          | Yes     | GRCh37.DRAGEN\_4.5.premium.json          |
| tmb              | Yes     | GRCh37.DRAGEN\_4.5.tmb.json              |

#### Category: germline-tagging

Run config: `GRCh37.DRAGEN_4.5.germline-tagging.json`

| Source         | Data Type      | Version                    |
| -------------- | -------------- | -------------------------- |
| ABRaOM         | SmallVariant   | SABE\_609\_exomes\_trimmed |
| GenomeAssembly | GenomeAssembly | GRCh37.p13                 |
| gnomad         | SmallVariant   | 2.1\_trimmed               |
| oneKg          | SmallVariant   | Phase 3 v5a\_trimmed       |

#### Category: methylation

Run config: `GRCh37.DRAGEN_4.5.methylation.json`

| Source         | Data Type         | Version      |
| -------------- | ----------------- | ------------ |
| Ensembl        | GeneModels        | 110          |
| GenomeAssembly | GenomeAssembly    | GRCh37.p13   |
| HGNC           | GeneModels        | 20240603     |
| RefSeq         | GeneModels        | 105.20220307 |
| UcscCpgIsland  | MethylationRegion | 20200322     |

#### Category: premium (premium)

Run config: `GRCh37.DRAGEN_4.5.premium.json`

| Source           | Data Type            | Version           |
| ---------------- | -------------------- | ----------------- |
| ABRaOM           | SmallVariant         | SABE\_609\_exomes |
| DANN             | Score                | 20200205          |
| DECIPHER         | StructuralVariant    | 201509            |
| Ensembl          | GeneModels           | 110               |
| FusionCatcher    | GeneFusion           | 1.33              |
| GME              | SmallVariant         | 20160618          |
| GenomeAssembly   | GenomeAssembly       | GRCh37.p13        |
| Gerp             | Score                | 20110522          |
| HGNC             | GeneModels           | 20240603          |
| MultiZ100Way     | Protein              | 20150427          |
| PrimateAI        | SmallVariant         | 0.2               |
| PromoterAI       | SmallVariant         | 1.1               |
| REVEL            | SmallVariant         | 20200205          |
| RefSeq           | GeneModels           | 105.20220307      |
| TOPMed           | SmallVariant         | freeze\_5         |
| UcscCpgIsland    | MethylationRegion    | 20200322          |
| alphaMissense    | SmallVariant         | 1.0               |
| clingen          | Gene                 | 20250815          |
| clingen          | StructuralVariant    | 20250815          |
| clingen (legacy) | StructuralVariant    | 20160414          |
| clinvar          | SmallVariant         | 20250601          |
| clinvar          | StructuralVariant    | 20250601          |
| clinvar-preview  | SmallVariant         | 20250601          |
| clinvar-preview  | StructuralVariant    | 20250601          |
| cosmic           | Gene                 | 102               |
| cosmic           | GeneFusion           | 102               |
| cosmic           | SmallVariant         | 102               |
| dbSNP            | SmallVariant         | 157               |
| globalAllele     | SmallVariant         | 151               |
| gnomad           | Gene                 | 4.1               |
| gnomad           | LowComplexityRegions | 2.1               |
| gnomad           | SmallVariant         | 2.1               |
| gnomad           | StructuralVariant    | 2.1               |
| gnomad-exome     | SmallVariant         | 2.1               |
| mitomap          | SmallVariant         | 20200819          |
| mitomap          | StructuralVariant    | 20200819          |
| omim             | Gene                 | 20250815          |
| oneKg            | RefMinor             | Phase 3 v5a       |
| oneKg            | SmallVariant         | Phase 3 v5a       |
| oneKg            | StructuralVariant    | Phase 3 v5a       |
| phylopScore      | ConservationScore    | hg19              |
| primateAI-3D     | SmallVariant         | 1.0               |
| spliceAI         | SmallVariant         | 1.3               |

#### Category: tmb (premium)

Run config: `GRCh37.DRAGEN_4.5.tmb.json`

| Source         | Data Type      | Version                    |
| -------------- | -------------- | -------------------------- |
| ABRaOM         | SmallVariant   | SABE\_609\_exomes\_trimmed |
| Ensembl        | GeneModels     | 110                        |
| GenomeAssembly | GenomeAssembly | GRCh37.p13                 |
| HGNC           | GeneModels     | 20240603                   |
| RefSeq         | GeneModels     | 105.20220307               |
| clinvar        | SmallVariant   | 20250601\_trimmed          |
| cosmic         | SmallVariant   | 102\_trimmed               |
| gnomad         | SmallVariant   | 2.1\_trimmed               |
| oneKg          | SmallVariant   | Phase 3 v5a\_trimmed       |

## Assembly: GRCh38

### Catalog: May 2026 (`20260501`) — Released 2026-05-01

Categories in this catalog:

| Category         | Premium | Run Config                            |
| ---------------- | ------- | ------------------------------------- |
| basic            | No      | GRCh38.20260501.basic.json            |
| germline-tagging | No      | GRCh38.20260501.germline-tagging.json |
| methylation      | No      | GRCh38.20260501.methylation.json      |
| premium          | Yes     | GRCh38.20260501.premium.json          |
| tmb              | Yes     | GRCh38.20260501.tmb.json              |

#### Category: basic

Run config: `GRCh38.20260501.basic.json`

| Source           | Data Type            | Version                        |
| ---------------- | -------------------- | ------------------------------ |
| ABRaOM           | SmallVariant         | SABE-WGS-1171                  |
| DANN             | Score                | 20200205                       |
| DECIPHER         | StructuralVariant    | 201509                         |
| Ensembl          | GeneModels           | 115                            |
| FusionCatcher    | GeneFusion           | 1.33                           |
| GME              | SmallVariant         | 20160618                       |
| GenomeAssembly   | GenomeAssembly       | GRCh38.p14                     |
| Gerp             | Score                | 20110522                       |
| HGNC             | GeneModels           | 20260209                       |
| MultiZ100Way     | Protein              | 20171006                       |
| REVEL            | SmallVariant         | 20200205                       |
| RefSeq           | GeneModels           | GCF\_000001405.40-RS\_2025\_08 |
| TOPMed           | SmallVariant         | freeze\_5                      |
| UcscCpgIsland    | MethylationRegion    | 20221018                       |
| alphaMissense    | SmallVariant         | 1.0                            |
| clingen          | Gene                 | 20260505                       |
| clingen          | StructuralVariant    | 20260505                       |
| clingen (legacy) | StructuralVariant    | 20160414                       |
| clinvar          | SmallVariant         | 20260328                       |
| clinvar          | StructuralVariant    | 20260328                       |
| clinvar-preview  | SmallVariant         | 20250601                       |
| clinvar-preview  | StructuralVariant    | 20250601                       |
| dbSNP            | SmallVariant         | 157                            |
| globalAllele     | SmallVariant         | 151                            |
| gnomad           | Gene                 | 4.1.1                          |
| gnomad           | LowComplexityRegions | 2.1                            |
| gnomad           | SmallVariant         | 4.1                            |
| gnomad           | StructuralVariant    | 4.1                            |
| gnomad-exome     | SmallVariant         | 4.1                            |
| mitomap          | SmallVariant         | 20200819                       |
| mitomap          | StructuralVariant    | 20200819                       |
| oneKg            | RefMinor             | Phase 3 v3plus                 |
| oneKg            | SmallVariant         | Phase 3 v3plus                 |
| oneKg            | StructuralVariant    | Phase 3 v5a                    |
| phylopScore      | ConservationScore    | hg38                           |
| phylopScore      | Score                | 1.0                            |

#### Category: germline-tagging

Run config: `GRCh38.20260501.germline-tagging.json`

| Source         | Data Type      | Version                 |
| -------------- | -------------- | ----------------------- |
| ABRaOM         | SmallVariant   | SABE-WGS-1171\_trimmed  |
| GenomeAssembly | GenomeAssembly | GRCh38.p14              |
| gnomad         | SmallVariant   | 4.1\_trimmed            |
| gnomad-exome   | SmallVariant   | 4.1\_trimmed            |
| oneKg          | SmallVariant   | Phase 3 v3plus\_trimmed |

#### Category: methylation

Run config: `GRCh38.20260501.methylation.json`

| Source         | Data Type         | Version                        |
| -------------- | ----------------- | ------------------------------ |
| Ensembl        | GeneModels        | 115                            |
| GenomeAssembly | GenomeAssembly    | GRCh38.p14                     |
| HGNC           | GeneModels        | 20260209                       |
| RefSeq         | GeneModels        | GCF\_000001405.40-RS\_2025\_08 |
| UcscCpgIsland  | MethylationRegion | 20221018                       |

#### Category: premium (premium)

Run config: `GRCh38.20260501.premium.json`

| Source           | Data Type            | Version                        |
| ---------------- | -------------------- | ------------------------------ |
| ABRaOM           | SmallVariant         | SABE-WGS-1171                  |
| DANN             | Score                | 20200205                       |
| DECIPHER         | StructuralVariant    | 201509                         |
| Ensembl          | GeneModels           | 115                            |
| FusionCatcher    | GeneFusion           | 1.33                           |
| GME              | SmallVariant         | 20160618                       |
| GenomeAssembly   | GenomeAssembly       | GRCh38.p14                     |
| Gerp             | Score                | 20110522                       |
| HGNC             | GeneModels           | 20260209                       |
| MultiZ100Way     | Protein              | 20171006                       |
| PrimateAI        | SmallVariant         | 0.2                            |
| PromoterAI       | SmallVariant         | 1.1                            |
| REVEL            | SmallVariant         | 20200205                       |
| RefSeq           | GeneModels           | GCF\_000001405.40-RS\_2025\_08 |
| TOPMed           | SmallVariant         | freeze\_5                      |
| UcscCpgIsland    | MethylationRegion    | 20221018                       |
| alphaMissense    | SmallVariant         | 1.0                            |
| clingen          | Gene                 | 20260505                       |
| clingen          | StructuralVariant    | 20260505                       |
| clingen (legacy) | StructuralVariant    | 20160414                       |
| clinvar          | SmallVariant         | 20260328                       |
| clinvar          | StructuralVariant    | 20260328                       |
| clinvar-preview  | SmallVariant         | 20250601                       |
| clinvar-preview  | StructuralVariant    | 20250601                       |
| cosmic           | Gene                 | 103                            |
| cosmic           | GeneFusion           | 103                            |
| cosmic           | SmallVariant         | 103                            |
| dbSNP            | SmallVariant         | 157                            |
| globalAllele     | SmallVariant         | 151                            |
| gnomad           | Gene                 | 4.1.1                          |
| gnomad           | LowComplexityRegions | 2.1                            |
| gnomad           | SmallVariant         | 4.1                            |
| gnomad           | StructuralVariant    | 4.1                            |
| gnomad-exome     | SmallVariant         | 4.1                            |
| mitomap          | SmallVariant         | 20200819                       |
| mitomap          | StructuralVariant    | 20200819                       |
| omim             | Gene                 | 20260505                       |
| oneKg            | RefMinor             | Phase 3 v3plus                 |
| oneKg            | SmallVariant         | Phase 3 v3plus                 |
| oneKg            | StructuralVariant    | Phase 3 v5a                    |
| phylopScore      | ConservationScore    | hg38                           |
| phylopScore      | Score                | 1.0                            |
| primateAI-3D     | SmallVariant         | 1.0                            |
| spliceAI         | SmallVariant         | 1.3                            |

#### Category: tmb (premium)

Run config: `GRCh38.20260501.tmb.json`

| Source         | Data Type      | Version                        |
| -------------- | -------------- | ------------------------------ |
| ABRaOM         | SmallVariant   | SABE-WGS-1171\_trimmed         |
| Ensembl        | GeneModels     | 112                            |
| GenomeAssembly | GenomeAssembly | GRCh38.p14                     |
| HGNC           | GeneModels     | 20240603                       |
| RefSeq         | GeneModels     | GCF\_000001405.40-RS\_2023\_10 |
| clinvar        | SmallVariant   | 20250601\_trimmed              |
| cosmic         | SmallVariant   | 102\_trimmed                   |
| gnomad         | SmallVariant   | 4.1\_trimmed                   |
| gnomad-exome   | SmallVariant   | 4.1\_trimmed                   |
| oneKg          | SmallVariant   | Phase 3 v3plus\_trimmed        |

### Catalog: Dragen 4.6 (`dragen-4.6`) — Released 2026-08-01

Categories in this catalog:

| Category         | Premium | Run Config                               |
| ---------------- | ------- | ---------------------------------------- |
| germline-tagging | No      | GRCh38.DRAGEN\_4.6.germline-tagging.json |
| methylation      | No      | GRCh38.DRAGEN\_4.6.methylation.json      |
| premium          | Yes     | GRCh38.DRAGEN\_4.6.premium.json          |
| tmb              | Yes     | GRCh38.DRAGEN\_4.6.tmb.json              |

#### Category: germline-tagging

Run config: `GRCh38.DRAGEN_4.6.germline-tagging.json`

| Source         | Data Type      | Version                 |
| -------------- | -------------- | ----------------------- |
| ABRaOM         | SmallVariant   | SABE-WGS-1171\_trimmed  |
| GenomeAssembly | GenomeAssembly | GRCh38.p14              |
| gnomad         | SmallVariant   | 4.1\_trimmed            |
| gnomad-exome   | SmallVariant   | 4.1\_trimmed            |
| oneKg          | SmallVariant   | Phase 3 v3plus\_trimmed |

#### Category: methylation

Run config: `GRCh38.DRAGEN_4.6.methylation.json`

| Source         | Data Type         | Version                        |
| -------------- | ----------------- | ------------------------------ |
| Ensembl        | GeneModels        | 112                            |
| GenomeAssembly | GenomeAssembly    | GRCh38.p14                     |
| HGNC           | GeneModels        | 20260209                       |
| RefSeq         | GeneModels        | GCF\_000001405.40-RS\_2023\_10 |
| UcscCpgIsland  | MethylationRegion | 20221018                       |

#### Category: premium (premium)

Run config: `GRCh38.DRAGEN_4.6.premium.json`

| Source           | Data Type            | Version                        |
| ---------------- | -------------------- | ------------------------------ |
| ABRaOM           | SmallVariant         | SABE-WGS-1171                  |
| DANN             | Score                | 20200205                       |
| DECIPHER         | StructuralVariant    | 201509                         |
| Ensembl          | GeneModels           | 112                            |
| FusionCatcher    | GeneFusion           | 1.33                           |
| GME              | SmallVariant         | 20160618                       |
| GenomeAssembly   | GenomeAssembly       | GRCh38.p14                     |
| Gerp             | Score                | 20110522                       |
| HGNC             | GeneModels           | 20260209                       |
| MultiZ100Way     | Protein              | 20171006                       |
| PrimateAI        | SmallVariant         | 0.2                            |
| PromoterAI       | SmallVariant         | 1.1                            |
| REVEL            | SmallVariant         | 20200205                       |
| RefSeq           | GeneModels           | GCF\_000001405.40-RS\_2023\_10 |
| TOPMed           | SmallVariant         | freeze\_5                      |
| UcscCpgIsland    | MethylationRegion    | 20221018                       |
| alphaMissense    | SmallVariant         | 1.0                            |
| clingen          | Gene                 | 20260505                       |
| clingen          | StructuralVariant    | 20260505                       |
| clingen (legacy) | StructuralVariant    | 20160414                       |
| clinvar          | SmallVariant         | 20260328                       |
| clinvar          | StructuralVariant    | 20260328                       |
| clinvar-preview  | SmallVariant         | 20250601                       |
| clinvar-preview  | StructuralVariant    | 20250601                       |
| cosmic           | Gene                 | 103                            |
| cosmic           | GeneFusion           | 103                            |
| cosmic           | SmallVariant         | 103                            |
| dbSNP            | SmallVariant         | 157                            |
| globalAllele     | SmallVariant         | 151                            |
| gnomad           | Gene                 | 4.1.1                          |
| gnomad           | LowComplexityRegions | 2.1                            |
| gnomad           | SmallVariant         | 4.1                            |
| gnomad           | StructuralVariant    | 4.1                            |
| gnomad-exome     | SmallVariant         | 4.1                            |
| mitomap          | SmallVariant         | 20200819                       |
| mitomap          | StructuralVariant    | 20200819                       |
| omim             | Gene                 | 20260505                       |
| oneKg            | RefMinor             | Phase 3 v3plus                 |
| oneKg            | SmallVariant         | Phase 3 v3plus                 |
| oneKg            | StructuralVariant    | Phase 3 v5a                    |
| phylopScore      | ConservationScore    | hg38                           |
| phylopScore      | Score                | 1.0                            |
| primateAI-3D     | SmallVariant         | 1.0                            |
| spliceAI         | SmallVariant         | 1.3                            |

#### Category: tmb (premium)

Run config: `GRCh38.DRAGEN_4.6.tmb.json`

| Source         | Data Type      | Version                        |
| -------------- | -------------- | ------------------------------ |
| ABRaOM         | SmallVariant   | SABE-WGS-1171\_trimmed         |
| Ensembl        | GeneModels     | 112                            |
| GenomeAssembly | GenomeAssembly | GRCh38.p14                     |
| HGNC           | GeneModels     | 20240603                       |
| RefSeq         | GeneModels     | GCF\_000001405.40-RS\_2023\_10 |
| clinvar        | SmallVariant   | 20250601\_trimmed              |
| cosmic         | SmallVariant   | 102\_trimmed                   |
| gnomad         | SmallVariant   | 4.1\_trimmed                   |
| gnomad-exome   | SmallVariant   | 4.1\_trimmed                   |
| oneKg          | SmallVariant   | Phase 3 v3plus\_trimmed        |

### Catalog: Dragen 4.5 (`dragen-4.5`) — Released 2026-01-01

Categories in this catalog:

| Category         | Premium | Run Config                               |
| ---------------- | ------- | ---------------------------------------- |
| germline-tagging | No      | GRCh38.DRAGEN\_4.5.germline-tagging.json |
| methylation      | No      | GRCh38.DRAGEN\_4.5.methylation.json      |
| premium          | Yes     | GRCh38.DRAGEN\_4.5.premium.json          |
| tmb              | Yes     | GRCh38.DRAGEN\_4.5.tmb.json              |

#### Category: germline-tagging

Run config: `GRCh38.DRAGEN_4.5.germline-tagging.json`

| Source         | Data Type      | Version                 |
| -------------- | -------------- | ----------------------- |
| ABRaOM         | SmallVariant   | SABE-WGS-1171\_trimmed  |
| GenomeAssembly | GenomeAssembly | GRCh38.p14              |
| gnomad         | SmallVariant   | 4.1\_trimmed            |
| gnomad-exome   | SmallVariant   | 4.1\_trimmed            |
| oneKg          | SmallVariant   | Phase 3 v3plus\_trimmed |

#### Category: methylation

Run config: `GRCh38.DRAGEN_4.5.methylation.json`

| Source         | Data Type         | Version                        |
| -------------- | ----------------- | ------------------------------ |
| Ensembl        | GeneModels        | 112                            |
| GenomeAssembly | GenomeAssembly    | GRCh38.p14                     |
| HGNC           | GeneModels        | 20240603                       |
| RefSeq         | GeneModels        | GCF\_000001405.40-RS\_2023\_10 |
| UcscCpgIsland  | MethylationRegion | 20221018                       |

#### Category: premium (premium)

Run config: `GRCh38.DRAGEN_4.5.premium.json`

| Source           | Data Type            | Version                        |
| ---------------- | -------------------- | ------------------------------ |
| ABRaOM           | SmallVariant         | SABE-WGS-1171                  |
| DANN             | Score                | 20200205                       |
| DECIPHER         | StructuralVariant    | 201509                         |
| Ensembl          | GeneModels           | 112                            |
| FusionCatcher    | GeneFusion           | 1.33                           |
| GME              | SmallVariant         | 20160618                       |
| GenomeAssembly   | GenomeAssembly       | GRCh38.p14                     |
| Gerp             | Score                | 20110522                       |
| HGNC             | GeneModels           | 20240603                       |
| MultiZ100Way     | Protein              | 20171006                       |
| PrimateAI        | SmallVariant         | 0.2                            |
| PromoterAI       | SmallVariant         | 1.1                            |
| REVEL            | SmallVariant         | 20200205                       |
| RefSeq           | GeneModels           | GCF\_000001405.40-RS\_2023\_10 |
| TOPMed           | SmallVariant         | freeze\_5                      |
| UcscCpgIsland    | MethylationRegion    | 20221018                       |
| alphaMissense    | SmallVariant         | 1.0                            |
| clingen          | Gene                 | 20250815                       |
| clingen          | StructuralVariant    | 20250815                       |
| clingen (legacy) | StructuralVariant    | 20160414                       |
| clinvar          | SmallVariant         | 20250601                       |
| clinvar          | StructuralVariant    | 20250601                       |
| clinvar-preview  | SmallVariant         | 20250601                       |
| clinvar-preview  | StructuralVariant    | 20250601                       |
| cosmic           | Gene                 | 102                            |
| cosmic           | GeneFusion           | 102                            |
| cosmic           | SmallVariant         | 102                            |
| dbSNP            | SmallVariant         | 157                            |
| globalAllele     | SmallVariant         | 151                            |
| gnomad           | Gene                 | 4.1                            |
| gnomad           | LowComplexityRegions | 2.1                            |
| gnomad           | SmallVariant         | 4.1                            |
| gnomad           | StructuralVariant    | 4.1                            |
| gnomad-exome     | SmallVariant         | 4.1                            |
| mitomap          | SmallVariant         | 20200819                       |
| mitomap          | StructuralVariant    | 20200819                       |
| omim             | Gene                 | 20250815                       |
| oneKg            | RefMinor             | Phase 3 v3plus                 |
| oneKg            | SmallVariant         | Phase 3 v3plus                 |
| oneKg            | StructuralVariant    | Phase 3 v5a                    |
| phylopScore      | ConservationScore    | hg38                           |
| phylopScore      | Score                | 1.0                            |
| primateAI-3D     | SmallVariant         | 1.0                            |
| spliceAI         | SmallVariant         | 1.3                            |

#### Category: tmb (premium)

Run config: `GRCh38.DRAGEN_4.5.tmb.json`

| Source         | Data Type      | Version                        |
| -------------- | -------------- | ------------------------------ |
| ABRaOM         | SmallVariant   | SABE-WGS-1171\_trimmed         |
| Ensembl        | GeneModels     | 112                            |
| GenomeAssembly | GenomeAssembly | GRCh38.p14                     |
| HGNC           | GeneModels     | 20240603                       |
| RefSeq         | GeneModels     | GCF\_000001405.40-RS\_2023\_10 |
| clinvar        | SmallVariant   | 20250601\_trimmed              |
| cosmic         | SmallVariant   | 102\_trimmed                   |
| gnomad         | SmallVariant   | 4.1\_trimmed                   |
| gnomad-exome   | SmallVariant   | 4.1\_trimmed                   |
| oneKg          | SmallVariant   | Phase 3 v3plus\_trimmed        |


---

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