Release Notes

Release Date: November 2025

These release notes describe the key changes to Illumina Preset Protocols (IPP) v2.11.

Compatibility

Refer to Compatibility under Instruments & Integrations.

New Features & Updates

• The updated MiSeq i100 Series Sequencing v2.0 protocol supports MiSeq i100 Series Integration Package v1.1.0 and MiSeq i100 Series On-Prem Integration Package v1.1.0.

Conflicts may occur when upgrading from IPP v2.10 to IPP v2.11 due to new sequencing workflow for MiSeq i100 Series. Refer to IPP Integration v2.11 Manual Upgrade for details.

• Added new parameters (--removeOnPremConfig and --removeUPA) to Illumina Preset Protocol Installer. Refer to Illumina Preset Protocols v2.11 Installation and User Configuration for details.

Known Issues

Importing workflows from IPP on Clarity v6.2 and v6.3 requires longer time (~8 times longer) compared to earlier versions (Clarity v6.1 and below). This issue is fixed in Clarity v6.3.1.

Additional References

Refer to these additional release notes for new features, updates and defects fixed for instrument integration protocols:

• MiSeq i100 Series On-Prem Integration v1.1.0 Release Notes

• MiSeq i100 Series Integration v1.1.0 Release Notes