# Variant Filters

The Variant Filters section describes how to add, configure, duplicate, or archive variant filters.

## Add and Configure a Variant Filter

1. On the top toolbar, select **Configuration**.
2. Select the **Test Components** tab.
3. Navigate to Variant Filters and select **New**.
4. Navigate to the Condition Group section and enter the applicable genes in the Genes field.
5. \[Optional] Select the **Include genes from diseases** check box.
6. Select **Apply**.
7. Select **Include** or **Exclude** from the drop-down list for each gene.
8. For Variant Category, select the field to open up a drop-down list of variants that can be included or excluded.
9. Select the check boxes next to the applicable variant types.
10. Select **Add Criteria** and select the applicable criteria from the drop-down list (for example, Cancer Hotspot Samples).
11. Select Include or Exclude from the drop-down list for the criteria.
12. To include or exclude additional criteria, repeat steps 10 and 11.
13. For AND or OR, select **Add Condition Group** to add any other applicable condition groups.
14. \[Optional] Select **Reset** to undo the changes to the condition groups.
15. Select **Save**.

> The Genomic Region criteria is not available when creating a filter from configuration but can be included when adding/editing filters in Variant grid . For more information, refer to [Add and Configure a Variant Filter](#add-and-configure-a-variant-filter).

## Edit a Variant Filter

1. On the top toolbar, **select Configuration**.
2. Select the **Test Components** tab.
3. For Variant Filters, select a filter.
4. Select **Edit**.
5. Update the applicable settings. For more information, refer to [Add and Configure a Variant Filter](#add-and-configure-a-variant-filter).
6. Select **Save**.

## Duplicate a Variant Filter

1. On the top toolbar, select **Configuration**.
2. Select the **Test Components** tab.
3. For Variant Filters, select the applicable filter.
4. In the right-hand pane, select **Duplicate**.
5. \[Optional] Adjust the condition group settings. For more information, refer to [Add and Configure a Variant Filter](#add-and-configure-a-variant-filter).
6. Select **Save**.

## Archive a Variant Filter

1. On the top toolbar, select **Configuration**.
2. Select the **Test Components** tab.
3. For Variant Filters, select the applicable filter.
4. In the right-hand pane, select **Archive**.
5. To confirm, select **Yes, change**.

## Default Filters

Connected Insights provides the following default filters to assist in preliminary test implementation:

| All Demo        | Filters for oncogenic, likely oncogenic, 1A, 1B, and 2C small variants, copy number variants, unidirectional gene fusions, and RNA splice variants. |
| --------------- | --------------------------------------------------------------------------------------------------------------------------------------------------- |
| SNV Demo        | Filters for oncogenic, likely oncogenic, 1A, 1B, and 2C small variants.                                                                             |
| CNV Demo        | Filters for oncogenic, likely oncogenic, 1A, 1B, and 2C copy number variants.                                                                       |
| SV Demo         | Filters for oncogenic, likely oncogenic, 1A, 1B, and 2C unidirectional gene fusions.                                                                |
| RNA Splice Demo | Filters for oncogenic, likely oncogenic, 1A, 1B, and 2C RNA splice variants.                                                                        |
| AML Demo        | Filters for AML-related variants based on WHO 2022 and ELN 2022 guidelines.                                                                         |


---

# Agent Instructions: Querying This Documentation

If you need additional information that is not directly available in this page, you can query the documentation dynamically by asking a question.

Perform an HTTP GET request on the current page URL with the `ask` query parameter:

```
GET https://help.connected.illumina.com/connected-insights/configure/configuration/c-variant-filters.md?ask=<question>
```

The question should be specific, self-contained, and written in natural language.
The response will contain a direct answer to the question and relevant excerpts and sources from the documentation.

Use this mechanism when the answer is not explicitly present in the current page, you need clarification or additional context, or you want to retrieve related documentation sections.