Overview

The below data flow diagram demonstrates processing workflow involving sequencing data from an Illumina instrument, which is mounted on the NAS (Network-Attached Storage). The DRAGEN software installed on the DRAGEN server v4, accesses the sequencing data from the NAS for secondary analysis. Upon completion of the secondary analysis, Connected Insights - Local reads the analysis output (.vcfs, .FASTQs), processes and annotates it for variant interpretation and writes back the results to the mounted storage.

Below is illustration of network interaction of Connected Insights - Local

Before installing the Connected Insights - Local software, review and complete the prerequisites. For instructions, refer to Prerequisites.

Once the prerequisites are met, complete the installation of Connected Insights - Local software in the sequence below:

1. Download the Connected Insights - Local software packages. For instructions refer to Download Connected Insights - Local software Package

2. Install the Illumina Administration Console software. For instructions, refer to Install Illumina Local installer software

3. Setup first administrator user and Sign in to Illumina Local installer software. For instructions, refer to Sign In to Connected Insights - Local software

4. Configure external storage. For instructions, refer to Configure External Storage

5. Install the Connected Insights - Local software. For instructions, refer to Install Connected Insights - Local Software

6. Install the Connected Insights - Local software setup license file and upload the Genome Equivalence sample balance file. For instructions, refer to Install License Files.

7. Install Annotations, Genome Data Reference and Knowledge Bases packages from Software updates page. For instructions, refer to Software Updates section Install or Update software and dependent package.

After completing the above installation instructions, follow the instructions in Configuration to set up test configurations and Data Upload from User Storage (Connected Insights - Cloud and Connected Insights - Local) to ingest cases from secondary analysis data.