# Create Gene Descriptions

* A gene description summarizes gene function and its association with diseases.
* It provides context for variant interpretation and often appears before the variant summary in reports.
* Users can create gene descriptions separately from variants in their knowledge base.

## Creating Gene Descriptions

* Users can create gene descriptions from scratch or based on external knowledge bases.
* These descriptions automatically apply to all variants within a gene.
* Collaborative editing and approval processes are available. See [Manage Assertions](https://help.connected.illumina.com/connected-insights/interpret-and-report/inter-interp-a-variant/inter-manage-assertions) for more details.

To create from scratch:

* Go to the Biomarker Details page.
* Click **Create New Assertion**.
* In the **Gene Description** tab, specify the gene role (e.g., Oncogene or Tumor Suppressor), provide a summary, and set the approval status.
* Curating gene roles helps with variant interpretation (i.e., providing input for oncogenicity prediction).

From an external knowledge base:

* Navigate to the Biomarker Details page.
* Choose a gene description from an external knowledge base (e.g., CKB).
* Select **Copy to new assertion** in the menu next to "Report".
* Edit the fields as needed.