> For the complete documentation index, see [llms.txt](https://help.connected.illumina.com/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://help.connected.illumina.com/connected-insights/interpret-and-report/viewdetails-introduction/viewdetails-clinical-trials.md).

# Clinical Trials

The Clinical Trials provides a list of all the clinical trials that have a match for the variant.

By default, the assertions are filtered by the case and ancestor diseases. You can also filter by diseases, title, city, state, and country. Filter changes are saved and applied across variants within a case and can be reset if needed.

Classification is reported as Tier 2C (or equivalent, using your [Actionability Classifications](/connected-insights/configure/configuration/c-custom-actionability-classification.md)).

### Clinical Trials Legend

<table data-header-hidden><thead><tr><th width="191">Field Name</th><th>Description</th></tr></thead><tbody><tr><td>Field Name</td><td>Description</td></tr><tr><td>Source</td><td>Knowledge base origin of the clinical trial.</td></tr><tr><td>Biomarker / Status</td><td>Indicates how the assertion is related to the variant (for example, specific amino acid change or specific exon change).<br><br>Indicates the TMB, MSI, or GIS status for the clinical trial. This column is available for TMB, MSI, and GIS.</td></tr><tr><td>HRD</td><td>Indicates whether a clinical trial is associated with HRD positive or negative. This column is available for GIS and variants, when the selected transcript is for BRCA1/2.</td></tr><tr><td>Title</td><td>Title of the clinical trial.</td></tr><tr><td>Phase</td><td>Phase of the clinical trial.</td></tr><tr><td>Location</td><td>Location of the clinical trial.</td></tr><tr><td>Disease</td><td>Disease for the clinical trial.</td></tr><tr><td>Link-out Icon</td><td>Select to display the full listing about the trial in a new browser tab.</td></tr><tr><td>Previously Reported Icon</td><td>Any cases where the assertion was previously reported.</td></tr><tr><td>Actions</td><td>This column contains the following available actions:<br>• Add to report<br>• Archive, if the assertion is in My Knowledge Base<br>• Copy to New Assertion, if the assertion is not in My Knowledge Base<br><br>To edit an assertion, add it to the report before editing. For more information, refer to <a href="/pages/HqkoElM87bMRuPjxus13#editing-assertions">Manage Assertions</a>.</td></tr></tbody></table>

## Available Clinical Trials Knowledge Bases

Connected Insights provides the Genomenon Cancer Knowledge Base (formerly Jackson Laboratory Clinical Knowledge Base), which includes curated clinical trials from clinicaltrials.gov. For more information, refer to the [Genomenon CKB website](https://ckbhome.genomenon.com/). See [this page](https://ckbhome.genomenon.com/about/glossaryOfTerms) for assertion descriptions.

Clinical trials with a recruitment status of completed, withdrawn, or active, not recruiting are not supported.


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