Clinical Trials
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Clinical trials are listed in this when one of the knowledge bases determines the trial to be a match for the variant. The information in this table is from the clinical trial database.
By default, the assertions are filtered by the case and ancestor diseases. Ancestor diseases are determined using SNOMEDCT. These diseases can be viewed at the , with the following exceptions:
Descendents of neoplastic disease do not include ancestors beyond neoplastic disease.
Non-small cell lung cancer has been added as an ancestor of adenocarcinoma of lung.
You can also filter by other diseases, title, city, state, and country. Filter changes are saved and applied across variants within a case and can be reset if needed.
Field Name
Description
Source
Knowledge base origin of the clinical trial.
Status
Indicates the TMB, MSI, or GIS status for the clinical trial. This column is available for TMB, MSI,and GIS.
HRD
Indicates whether a clinical trial is associated with HRD positive or negative. This column is available for GIS and variants, when the selected transcript is for BRCA1/2.
Biomarker
Indicates how the assertion is related to the variant (for example, specific amino acid change or specific exon change).
Title
Title of the clinical trial.
Phase
Phase of the clinical trial.
Location
Location of the clinical trial.
Disease
Disease for the clinical trial.
Actions
The following from CKB is not currently supported:
Clinical trials with a recruitment status of completed, withdrawn, or active, not recruiting.
Variants that have the excluded requirement type.
The software does not yet determine if a case has all the requirements for a clinical trial (for example, a clinical trial requires two variants).
This column contains the following available actions: • Select the hyperlink to display the full listing about the trial in a new browser tab. • Add to report • Archive, if the assertion is in My Knowledge Base • Copy to New Assertion, if the assertion is not in My Knowledge Base • View past cases To edit an assertion, add it to the report before editing. For more information, refer to .
Connected Insights provides the Genomenon Cancer Knowledge Base (formerly Jackson Laboratory Clinical Knowledge Base), which includes curated clinical trials from clinicaltrials.gov. For more information, refer to the .