# Gene Overview

This section is only available for variants that overlap a transcript.

## Gene symbols

A searchable dropdown shows all genes that the variant overlaps. Select one to view the information below.

## Gene Descriptions

<table><thead><tr><th width="164">Column</th><th>Description</th></tr></thead><tbody><tr><td>Update Date</td><td>The last date that the assertion was updated.</td></tr><tr><td>Source</td><td>Knowledge base origin of the gene description.</td></tr><tr><td>Role</td><td>The specified gene role.</td></tr><tr><td>Summary</td><td>Gene description.</td></tr><tr><td>Previously Reported Icon</td><td>Any cases where the assertion was previously reported.</td></tr><tr><td>Actions</td><td>This column contains the following available actions:<br>• Add to report<br>• Archive, if the assertion is in My Knowledge Base<br>• Copy to New Assertion, if the assertion is not in My Knowledge Base<br><br>To edit an assertion, add it to the report before editing. For more information, refer to <a href="../../inter-interp-a-variant/inter-manage-assertions#editing-assertions">Manage Assertions</a>.</td></tr></tbody></table>

### Available Knowledge Bases

**Memorial Sloan Kettering OncoKB**

Connected Insights provides the Memorial Sloan Kettering OncoKB. For more information, refer to the OncoKB website.

**Jackson Clinical Knowledge Base (JAX-CKB)**

Connected Insights provides the Jackson Clinical Knowledge Base (JAX-CKB). For more information, refer to the Jackson CKB website.

**Clinical Interpretation of Variants in Cancer (CIViC)**

Connected Insights also provides the Clinical Interpretation of Variants in Cancer (CIViC) knowledge base. For more information, refer to the CIViC website.

## Gene-Related Diseases

The associated phenotypes in ClinGen and OMIM databases and links to open the entries in the databases in a new browser tab.

## Gene Expression

Gene expression is shown in transcripts per million (TPM) if provided by the secondary analysis pipeline (e.g., DRAGEN RNA).

## External Links

The following external links are included in this section:

* PubMed
* MGI
* DECIPHER
* GeneReviews
* Monarch
* ZFIN
* STRING


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