# DRAGEN Enrichment

There are multiple ways that the DRAGEN Enrichment workflow can be run. Please follow the appropriate instructions for the desired workflow:

* [Somatic High Coverage](/dragen-5-base/run-analysis-setup/local-dragen-server-analysis-setup/dragen-enrichment/somatic-high-coverage.md)
* [Somatic Medium Coverage](/dragen-5-base/run-analysis-setup/local-dragen-server-analysis-setup/dragen-enrichment/somatic-medium-coverage.md)
* [Somatic Low Coverage](/dragen-5-base/run-analysis-setup/local-dragen-server-analysis-setup/dragen-enrichment/somatic-low-coverage.md)
* [Enrichment Germline](/dragen-5-base/run-analysis-setup/local-dragen-server-analysis-setup/dragen-enrichment/enrichment-germline.md)

### Coverage Rate Minimums

The following coverage rates are the minimums recommended for each of the various workflows:

* High Coverage
  * Post-Collapsed Coverage Rate >2000x (liquid tumor mode)
* Medium Coverage
  * Post-Collapsed Coverage Rate 200-300x (solid tumor mode)
* Low Coverage
  * Coverage Rate >20x for Germline Methyl-Only
  * Coverage Rate >30x for Germline Methyl + VC
  * Coverage Rate >100x for Somatic Methyl + VC

**If the UMI-collapsed reads do not meet the recommended post-collapsed coverage depths for the solid tumor or liquid biopsy pipelines, then it is recommended to run with the default UMI settings**


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