# DRAGEN Array Methylation QC Cloud v1.0.0 Release Notes

## RELEASE DATE

May 2024

## RELEASE HIGHLIGHTS

* Adjustable thresholds to determine pass/fail status
* Data summary plots for a quick visual check of each analysis batch
* Determining detection p-value, beta-values, and m-values from each methylation sample
* Deployment on BaseSpace™ Sequence Hub user interface for easy analysis kickoff

## NEW FEATURES IN DETAIL

* Adjustable thresholds for 21 built in controls, p-value detection, proportion probes passing, and offset correction within BaseSpace Sequence Hub to customize for user’s study needs
  * Thresholds are used to assign pass (1) or fail (0) status to each sample
    * Failed metrics can be highlighted for easy viewing
  * Pinpoint areas of failure including bisulfite conversion, staining, hybridization, etc. to identify assay steps in need of troubleshooting
  * Quantitative values for each control removing ambiguity with manual interpretation
* Data summary plots with information on passing p-value detection and principal component analysis of beta values
* Provides detection p-value, beta-values and m-values for each CG site per sample to use in downstream analysis

## KNOWN ISSUES

## KNOWN LIMITATIONS

* Standard thresholds may not be applicable for all discontinued, semi-custom or custom BeadChips and IDATs originating from NextSeq550
* Built-in controls may not be available on all discontinued, semi-custom or custom BeadChips