# About DRAGEN somatic for IDT Custom Panels

DRAGEN somatic for IDT custom panels v4.5.4 is a cloud-based bioinformatics solution for somatic sequencing data. It analyzes data generated with IDT's xGen cfDNA and FFPE library prep kit.

The pipeline is pre-optimized for this IDT library chemistry, so you do not need to tune parameters manually. It accepts your custom panel BED file as input and runs end-to-end on Illumina Connected Analytics (ICA) or BaseSpace Sequence Hub (BSSH).

## Supported Biomarkers

This release (Powered by DRAGEN v4.5.4) supports the following DNA biomarkers:

* Single nucleotide variants (SNVs)
* Insertions and deletions (indels)
* Tumor mutational burden (TMB)

{% hint style="info" %}
**Current scope.** This release is optimized for DNA extracted from tumor tissue (FFPE or fresh/frozen samples) in tumor-only mode from the Run Planner interface and the DRAGEN for IDT Custom Panels app interface (BSSH/ICA). Tumor-normal is available from the DRAGEN for IDT Custom Panels app (BSSH/ICA) only.
{% endhint %}

## Supported reference genomes

* hg38 v6
* hg38 v6 with pangenome
* hg19 v6
* hg19 v6 with pangenome

## Supported Analysis Modes

This release (v4.5.4) supports the following analysis modes in both Tumor-Normal (T/N) and Tumor-Only (T/O) modes:

* UMI workflow
* Non-UMI workflow
* Low-quality FFPE mode

## Sequencer compatibility

This solution can be used with any of Illumina's sequencers. For specifics about how to set up Run Planner with a particular sequencer, please refer to its documentation.


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