# Connecting to Connected Insights

After the DRAGEN for IDT Custom Panels pipeline completes, you can import the VCF output into **Illumina Connected Insights** for variant interpretation, annotation, and clinical research reporting.

## What Connected Insights Provides

* **OncoKB, CKB, and CIViC** knowledge bases for biological classification and actionability
* Lab's own **My Knowledge Base**
* **Standard-based oncogenicity prediction**
* **Somatic/Germline knowledge base matching** based on variant origin
* Customizable **QC metrics and coverage thresholds**
* Customizable **TMB threshold per disease group**
* **Advanced variant filtering and prioritization**
* **Report automation**
* Flexible report templates supporting **PDF and DOCX**
* Best-in-class visualization, plus **IGV support**

## How to Connect

Illumina Connected Insights is a software solution for interpretation and reporting of NGS data. It accepts VCF files from various analysis pipelines, annotates variants with genomic databases, and generates customized reports.

* If you configured your BaseSpace Sequence Hub (BSSH) settings to send data to Illumina Connected Analytics (ICA) **before** sequencing, Connected Insights can automatically ingest your results.
* Alternatively, manually import the ICA analysis or ICA folder into Connected Insights.
* For automated workflows, configure a **Test Definition** in Connected Insights and link it to the DRAGEN pipeline output via the Data Upload settings.

For setup instructions, refer to the [Illumina Connected Insights Data Upload (ICA) documentation](https://help.connectedinsights.illumina.com/configure/configuration/du-introduction/du-ica).

{% hint style="success" %}
**Setup recommendation.** Configure your BSSH settings to send sequencing run data to ICA **before** sequencing. This enables you to use either ICA or BSSH to requeue analysis and to connect output files to Connected Insights. This step is not required for NovaSeq X Series instruments, which send data to ICA automatically. See [Prerequisites](/dragen-somatic-for-idt-custom-panels/get-started/prerequisites.md).
{% endhint %}


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