# Advanced Topics

## CRAM input

When CRAM is used as input, the reference genome used to generate the CRAM files is required. This may be provided using the [custom configuration file](https://github.com/illumina-swi/dragen-docs/blob/release/4.4-prod/product-guides/dragen-v4.4/user-guide/dragen-apps/dragen-solid-wgs-tn-pipeline/server/advanced/custom_config.md).