Biomarkers

DRAGEN biomarker support is tabulated below. Please refer to the respective sections for details on requirements and how to configure each module.

	WES T/N	WES T/O	WGS T/N	WGS T/O
HRD	Supported	Supported	Supported	Supported
MSI	Supported	Supported	Supported	Supported
TMB	Supported	Supported	Supported	Supported
Fragmentomics	Unsupported	Supported	Unsupported	Supported
Mutational Signatures	Unsupported[1],[2]	Unsupported[2]	Supported[1]	Supported

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^[1] All Tumor/Normal workflows automatically perform mutational signatures analysis with no additional options required.

^[2] WES sequences ~1% of the genome compared to WGS, resulting in ~1% of the somatic mutations available for analysis. While analysis execution is possible, it is not recommended; results are likely not reliable with such limited input.