Filters tab
The table below lists the available filter categories. In Different modes, a green check mark means the filter category supports Simple and Advanced filtering modes.
Narrow variants by sequencing quality metrics such as depth, mapping quality, and confidence grade
Filter by allele frequency and genotype counts from public databases (e.g., gnomAD, ExAC) or your lab’s internal controls
Select by predicted consequences on genes or proteins, ACMG classes, or database classifications
Apply computational prediction scores for pathogenicity, conservation, splicing, or missense effects
Restrict results to genes of interest, such as disease–associated, candidate, ACMG actionable, or cancer–related genes
Highlight variants in genes with known disease associations matching the proband’s phenotypes
(v100.40.0+)
Filter variants according to inheritance patterns consistent with family genotypes and phenotypes
Show variants tagged by users, AI shortlist, or flagged at the organization level
Quality, Polymorphism, Variant effect, In silico prediction, Phenomatch filters (v100.40.0+), and Evidence & Tags filters can operate in either a simple or advanced mode.
Use Simple mode for quick, high-level filtering. For more detailed filtering with expanded options, choose Advanced mode to gain deeper control over filter parameters.
Simple and advanced filtering modes operate independently.
Even with similar settings, results may differ due to variations in filtering logic and options available.
For example, setting Severity to "High" in simple mode might yield slightly different results than selecting all high severity Main effect options in advanced mode of Variant effect filters.
Use the Filters tab in the Filtering panel to narrow the variant list by applying filtering conditions. Filters are applied to the variant table and update results as you refine your criteria.
Filter operators modes
The Filters tab operates in two filter operators modes: Simple and Advanced.
Simple filter operators mode:
Filtering logic is predefined and not configurable.
Use Simple filter operators mode for common filtering scenarios where explicit control over filtering logic is not required.
Advanced filter operators mode (v100.40.0+):
Filtering logic is explicit and user-defined, and additional filters are available.
Use Advanced filter operators mode for filtering logic that is complex, requires precise control, or includes filters that are only available in Advanced filter operators mode.
Filter settings are saved separately for each filter operators mode for the current session. Switching between modes does not clear or merge those settings, except when you select Clear in Advanced filter operators mode (see below).
Understand filter operators modes vs category-level filtering modes
Filter operators modes define how filters are combined in the Filters tab:
Simple: Filtering logic is implicit.
Advanced: Filtering logic is explicit and user-defined.
Per-category filtering modes are available for some filter categories in Simple filter operators mode. They affect the options available within that category:
Simple: High-level filters.
Advanced: Expanded filters.
Learn more about category-level modes here.
Switch between filter operators modes
In Analysis tools, open the Filters tab.
Select Switch to Advanced on top of the Filters tab to enter Advanced filter operators mode.
To return to Simple filter operators mode, select Switch to Simple.
Result: The selected filter operators mode is enabled. If you previously configured filters in that mode, they remain available.
Actions menu
Use the Actions menu (â‹®) to:
Clear filters
Reset filters to default settings
Save the current configuration as a preset
Warning: Clear and Reset to default in Advanced filter operators mode
Clear and Reset to default should not be used from Advanced filter operators mode.
If selected, Emedgene switches to Simple filter operators mode.
Clear also removes the current advanced query. This can cause you to lose your advanced filter setup in Advanced filter operators mode!
Learn more
Simple filter operators mode
Use default filter behavior to narrow variants with standard filter categories and default actions.
Advanced filter operators mode (v100.40.0+)
Build explicit filter logic with AND, OR, nested condition groups, and include or exclude rules.
Variant search
Refine active filters with ad hoc search terms for genes, phenotypes, diseases, and variant notation.
Presets tab
Save filter configurations as presets and apply predefined filtering strategies during case review.
Filtering panel
See how filters, presets, preset groups, and variant search work together during case review.
Last updated
Was this helpful?