Assign / Clear pathogenicity

Using bulk pathogenicity actions, you can set or clear classifications for multiple variants at once. This reduces repetitive work during interpretation. Only tagged variants can have pathogenicity assigned.

Assigning pathogenicity classifications to multiple variants

1

Select the variants of interest

2

In the Multi-select actions bar, click the Pathogenicity icon

3

Choose a classification

^{Pathogenic, Likely Pathogenic, VUS, Likely Benign, Benign}

Assigning pathogenicity to selected variants in v100.40.0.

Removing pathogenicity classifications from multiple variants

1

Select the variants of interest

2

In the Multi-select actions bar, click the Pathogenicity icon

3

Select Clear to remove the existing classification

• ^{Clearing pathogenicity removes existing classifications for all selected variants.}
• ^{Changes apply immediately and affect all users working on the case.}

Clearing pathogenicity for selected variants in v100.40.0.

Tips:

• Combine tags and pathogenicity assignments in bulk to streamline reporting preparation.
• Assign pathogenicity before exporting to avoid validation errors.