# Phenomatch filters

The Phenomatch filters identify **variants in genes whose disease phenotypes best match the proband’s clinical presentation**, using [proprietary phenotypic match models](https://help.connected.illumina.com/emedgene/emedgene-analyze-manual/reviewing_a_case/phenotypic-match/phenotypic-match-models) to rank genes by relevance.

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There is a corresponding filter for each phenotypic match model:

* **Phenomeld:** Most advanced model; provides the most accurate gene prioritization.
* **Phenomatch – Powered by AI:** Finds genes with **loose** phenotype similarity to the patient’s HPO terms.
* **Phenomatch – High specificity:** Finds genes with **exact** phenotype match to the patient’s HPO terms.
* **Phenomatch with unknown:** Finds genes of **unknown significance** through indirect associations (pathways, mouse models, gene families).
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## Default values

When filters are reset to default, the Phenomatch filters are not applied.


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