> For the complete documentation index, see [llms.txt](https://help.connected.illumina.com/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://help.connected.illumina.com/emedgene/emedgene-analyze-manual/reviewing_a_case/candidates-tab/most_likely_candidates_and_candidates.md). # Most Likely Candidates and Candidates To streamline case review, the **AI Shortlist** pre-selects the list of variants likely to be causative for each case: **Most Likely Candidates** and **Candidates**. ### **Most Likely Candidates** Variants that are most promising for solving the case. This list is limited to 10 top-scored variants but may include more if more than one variant is tagged per gene (suggesting compound heterozygosity). We can change the **Most Likely Candidates** number limit upon request. ### **Candidates** Several dozen highly scored variants worth considering. The ranking of variants by **AI Shortlist** considers: * SNVs * CNVs * SNV + CNV compound heterozygotes * SVs * mtDNA variants * STRs The **AI Shortlist** rates variants based on predicted variant effects, alternative allele frequency, familial segregation pattern, phenotypic match, in silico predictions, and other relevant information from scientific papers and databases. During the case review, you can untag variants selected by the **AI Shortlist** or manually tag ones not selected by the **AI Shortlist**. --- # Agent Instructions This documentation is published with GitBook. GitBook is the documentation platform designed so that both humans and AI agents can read, navigate, and reason over technical content effectively. Learn more at gitbook.com. ## Querying This Documentation If you need additional information that is not directly available in this page, you can query the documentation dynamically by asking a question. Perform an HTTP GET request on the current page URL with the `ask` query parameter, and the optional `goal` query parameter: ``` GET https://help.connected.illumina.com/emedgene/emedgene-analyze-manual/reviewing_a_case/candidates-tab/most_likely_candidates_and_candidates.md?ask=&goal= ``` `ask` is the immediate question: it should be specific, self-contained, and written in natural language. `goal` is optional and describes the broader end goal you are ultimately trying to accomplish on behalf of the user. GitBook uses it to tailor the answer towards what is most useful for that goal. The response will contain a direct answer to the question and relevant excerpts and sources from the documentation. Use this mechanism when the answer is not explicitly present in the current page, you need clarification or additional context, or you want to retrieve related documentation sections.