# Most Likely Candidates and Candidates ## To streamline case review, the AI Shortlist pre-selects the list of variants likely to be causative for each case: ### **Most Likely Candidates** Variants that are most promising for solving the case. This list is limited to 10 top-scored variants but may include more if more than one variant is tagged per gene (suggesting compound heterozygosity). We can change the Most Likely Candidates number limit upon request. ### **Candidates** Several dozen highly scored variants worth considering. The ranking of variants by AI Shortlist considers: * SNVs * CNVs * SNV + CNV compound heterozygotes * SVs * mtDNA variants * STRs The AI Shortlist rates variants based on predicted variant effects, alternative allele frequency, familial segregation pattern, phenotypic match, in silico predictions, and other relevant information from scientific papers and databases. During the case review, you can untag variants selected by the AI Shortlist or manually tag ones not selected by the AI Shortlist. --- # Agent Instructions: Querying This Documentation If you need additional information that is not directly available in this page, you can query the documentation dynamically by asking a question. Perform an HTTP GET request on the current page URL with the `ask` query parameter: ``` GET https://help.connected.illumina.com/emedgene/emedgene-analyze-manual/reviewing_a_case/candidates-tab/most_likely_candidates_and_candidates.md?ask= ``` The question should be specific, self-contained, and written in natural language. The response will contain a direct answer to the question and relevant excerpts and sources from the documentation. Use this mechanism when the answer is not explicitly present in the current page, you need clarification or additional context, or you want to retrieve related documentation sections.