> For the complete documentation index, see [llms.txt](https://help.connected.illumina.com/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://help.connected.illumina.com/emedgene/emedgene-analyze-manual/reviewing_a_case/phenotypic-match.md).

# Phenotypic match

Emedgene compares the proband’s phenotype profile with disease phenotypes associated with each gene.

This comparison produces phenotypic match scores that help rank genes by relevance to the proband’s clinical presentation. If a gene is linked to multiple diseases, the best-matching disease determines the displayed score.

Use phenotypic match to:

* Focus review on genes that best fit the core clinical presentation
* Interpret phenotype-driven evidence during variant prioritization
* Reduce the effect of less relevant phenotypes when weighting is needed (v100.40.0+)

### Learn more

<table data-view="cards"><thead><tr><th></th><th></th><th></th></tr></thead><tbody><tr><td><strong>Phenotypic match models</strong></td><td>Review the available scoring approaches and how each model matches disease phenotypes to the proband profile.</td><td><i class="fa-arrow-up-right-from-square">:arrow-up-right-from-square:</i> <a href="/pages/1zGgR9anzOmdOcGBbssn">Learn more</a></td></tr><tr><td><strong>Phenotypic match strength</strong></td><td>Interpret the similarity levels shown for phenotype matches during case review.</td><td><i class="fa-arrow-up-right-from-square">:arrow-up-right-from-square:</i> <a href="/pages/tLh79erRUfz2Xf2owwaV">Learn more</a></td></tr><tr><td><strong>Phenotype weights (v100.40.0+)</strong></td><td>Adjust phenotype weights to increase, reduce, or exclude their effect on live <strong>Phenomeld</strong> scoring.</td><td><i class="fa-arrow-up-right-from-square">:arrow-up-right-from-square:</i> <a href="/pages/ti4PJF5K4tgafQc5rzdA">Learn more</a></td></tr></tbody></table>


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