Configuring an organization database

1

Upon request, Illumina Support provisions the internal database VCF file from the customer’s cases based on supplied requirements.

Alternatively, the customer creates an external database VCF file and provides it to Illumina Support for upload.

2

Illumina Support stores the database in the customer’s secure bucket.

3

The user with appropriate permissions registers the database by selecting it from their bucket in Settings.

4

Once registered, the database appears in the Organization Databases list. From here, the customer can tune settings:

• Enable or disable its use in variant annotation.

• Enable or disable allele frequency usage by AI Shortlist for variant prioritization.