# Configuring an organization database

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Upon request, **Illumina Support** [**provisions**](https://help.connected.illumina.com/emedgene/emedgene-analyze-manual/settings/organization_settings_-330+/workbench-and-pipeline/organization-db-management/configuring-an-organization-database/creating-a-database-vcf-file/creating-an-internal-database-vcf-file) **the internal database** VCF file from the customer’s cases based on supplied requirements.

Alternatively, the **customer** [**creates**](https://help.connected.illumina.com/emedgene/emedgene-analyze-manual/settings/organization_settings_-330+/workbench-and-pipeline/organization-db-management/configuring-an-organization-database/creating-a-database-vcf-file/creating-an-external-database-vcf-file) **an external database** VCF file and provides it to Illumina Support for upload.
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Illumina Support stores the database in the customer’s secure bucket.
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The user with appropriate [permissions](https://help.connected.illumina.com/emedgene/emedgene-analyze-manual/settings/user_roles/iam-scopes-emedgene-roles) [**registers**](https://help.connected.illumina.com/emedgene/emedgene-analyze-manual/settings/organization_settings_-330+/workbench-and-pipeline/organization-db-management/configuring-an-organization-database/registering-a-database) the database by selecting it from their bucket in Settings.
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Once registered, the database appears in the Organization Databases list. From here, the customer can [**tune settings**](https://help.connected.illumina.com/emedgene/emedgene-analyze-manual/settings/organization_settings_-330+/workbench-and-pipeline/organization-db-management/configuring-an-organization-database/modifying-database-settings):

* **Enable or disable** its use in [variant annotation](https://help.connected.illumina.com/emedgene/emedgene-analyze-manual/tertiary-analysis-pipeline/annotations-from-organization-databases).
* **Enable or disable** allele frequency usage by AI Shortlist for variant prioritization.
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