Modifying database settings

Users with appropriate permissions can tune database settings within their organization.

1

Select Edit next to the database you want to update.

2

Modify database settings as needed:

• Active: Turn on to apply annotations from this database to variants in new and reanalyzed cases.
• AI Shortlist: Turn on to include allele frequencies from this database when prioritizing variants. When enabled, variants with an allele frequency greater than 10% are excluded from the shortlist.

  • Custom BED Annotation databases (v100.41+): AI Shortlist is always off and cannot be enabled.
• File: Select a different database file.

3

Select Save to apply the changes.

Result:

• The database settings are updated.
• The Last edited date reflects the change.
• An audit-log entry records the change for transparency and traceability.