# Clinical significance

The Clinical significance card provides insights into how a variant has been classified previously—both within your organization and across public databases. This helps you quickly assess existing interpretations and decide whether additional evidence is needed.

## Pathogenicity classification sources

* **Manually classified**

  Indicates if the variant was classified in any previous case in the account
* **Networks classified**

  Shows if the variant was classified by partner organizations in your [network](/emedgene/emedgene-analyze-manual/analyze_network.md)

{% hint style="danger" %}
**Known issue:** The **Networks classified** tab may occasionally appear empty in error. Until the fix is implemented, please rely on the [Related cases tab](/emedgene/emedgene-analyze-manual/variant_page/related_cases_section.md), which displays the relevant information.
{% endhint %}

* **Curate**\
  Displays whether the variant exists in your [Curate](broken://pages/JHmO0TJUuneVcw5IzKwJ) variant database
* **ClinVar**

  Lists ClinVar submissions for the variant
* **ClinGen Regions** (CNVs)\
  Indicates whether a variant overlaps a dosage-sensitive region defined by ClinGen
* **Organization database**\
  Shows classifications from [curated variant database(s)](/emedgene/emedgene-analyze-manual/settings/organization_settings_-330+/workbench-and-pipeline/organization-db-management/organization-databases.md#curated-database) maintained by your organization.
* **MITOMAP** (mtDNA variants)\
  Shows a variant's status in [MITOMAP](https://academic.oup.com/nar/article/24/1/177/2359869). By clicking on the MITOMAP interactive link, you will be taken to [MITOMAP: Reported Mitochondrial DNA Base Substitution Diseases: Coding and Control Region Point Mutations](https://www.mitomap.org/foswiki/bin/view/MITOMAP/MutationsCodingControl).


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