# Variant quality summary

The variant quality summary helps you assess the overall reliability of a variant call before reviewing detailed metrics. Overall quality appears at the top of the **Quality tab** for the proband and in the **Pedigree card** for all samples, as described below.

{% hint style="warning" %}
**Important:**

**Low quality ≠ irrelevant** — in rare cases, important variants may appear low quality due to mapping complexity (e.g., MRJD variants in paralogous regions).

Variants marked low quality may be hidden from your preset filters! Review them in IGV before discarding.
{% endhint %}

## Proband variant quality

At the top of the **Quality tab**, you can find:

* The overall variant quality in the proband sample, based on caller-specific rules
* A variant caller abbreviation and version

<div align="left"><figure><img src="/files/9yz41Xn5Bjr0TOeenSME" alt="" width="563"><figcaption><p>Variant quality for the proband at the top of the <strong>Quality tab</strong>.</p></figcaption></figure></div>

## Pedigree card

The **Pedigree card** is on the left side of the **Quality tab**. Here, each sample is represented by zygosity and a variant quality grade.

{% columns %}
{% column width="16.666666666666664%" valign="middle" %}

<div align="center"><figure><img src="/files/EOE3oGhYRUjPHXHJM9EQ" alt="" width="109"><figcaption><p>Sample icon in the <strong>Pedigree card</strong>.</p></figcaption></figure></div>
{% endcolumn %}

{% column width="41.66666666666667%" valign="middle" %}

#### Zygosity

Zygosity appears in the sample icon within the family tree.

Indicates whether the variant is:

* **HET**: Present in one allele
* **HOM**: Present in both alleles
* **HEMI**: Present on the X chromosome in males
* **REF**: Absent
  {% endcolumn %}

{% column width="41.66666666666668%" %}

#### Variant quality grade

Overall quality based on caller-specific rules.

Shown as a badge next to the sample icon:

* <img src="/files/HrQwffPUChYq6VSuEzzn" alt="" data-size="line"> High
* <img src="/files/kgUmzX8mFq1DOKX5e0xd" alt="" data-size="line"> Medium
* <img src="/files/R4knuDF9zOx5poHcrbpn" alt="" data-size="line"> Low
  {% endcolumn %}
  {% endcolumns %}


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# Agent Instructions: Querying This Documentation

If you need additional information that is not directly available in this page, you can query the documentation dynamically by asking a question.

Perform an HTTP GET request on the current page URL with the `ask` query parameter:

```
GET https://help.connected.illumina.com/emedgene/emedgene-analyze-manual/variant_page/quality_section/variant-quality-summary.md?ask=<question>
```

The question should be specific, self-contained, and written in natural language.
The response will contain a direct answer to the question and relevant excerpts and sources from the documentation.

Use this mechanism when the answer is not explicitly present in the current page, you need clarification or additional context, or you want to retrieve related documentation sections.