Variant page sidebar

The expandable Variant page sidebar provides access to key case information, integration with Alamut and IGV, and a detailed variant activity log—all within the Variant page.

To expand the sidebar, click the arrow icon in the top-right corner. Click it again to collapse the sidebar.

The sidebar includes three tabs:

Case info

The Case info tab displays sample names, BAM file locations (if available), affected vs. healthy sample status, and proband phenotypes.

Applications

The Applications tab lets you enable or disable connections with your IGV and Alamut desktop applications. This means there won't be any IGV and Alamut windows popping up unless you want them to!

Once you configure your connection preferences, they are saved to your user account and applied across all cases.

Activity

The Activity tab is your complete audit trail for a variant. It records variant-level user actions, including:

• Tagging variants

• Adding comments

• Drafting interpretation notes

• Editing the evidence graph

The timestamped logs support collaboration and maintain a traceable record of variant interpretation.

Best practices for using the Activity tab

• Review activities before finalizing a report, especially interpretation notes and ACMG classification updates.

• Coordinate with collaborators using comments, which are timestamped and tracked for team accountability.

• Use the activity log to validate automation outcomes, like auto-applied ACMG tags or updated evidence graphs.

• Document manual changes through comments if a known limitation applies (e.g., editing notes or gene list changes).