> For the complete documentation index, see [llms.txt](https://help.connected.illumina.com/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://help.connected.illumina.com/emedgene/emedgene-curate-manual/curate_genes_2_28/curate_gene_page/gene-metrics-card.md).

# Gene Metrics card

## Card contents

The **Gene Metrics card** displays gene metrics from ExAC, gnomAD and ClinGen that assess the potential pathogenic impact of gene alterations:

* **RVIS** — Residual variation intolerance score
* **p(LoF intolerant)** — Probability of loss of function intolerance
* **p(REC)** — Probability of being intolerant to homozygous, but not heterozygous LoF variants
* **O/E score** — Ratio of the observed/expected number of LoF variants
* **HI** — Haploinsufficiency
* **TS** — Triplosensitivity
* **Z missense** — Intolerance to missense variants based on the deviation of observed missense variants versus the expected number

<div align="left"><img src="https://1131024994-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FGCW0DnLlE7QjoZPNmKIi%2Fuploads%2Fgit-blob-3ab4719d906de1958542e3829c406c4606da7bbd%2Fcurate_gene_page_6_image.png?alt=media" alt="Gene Metrics card." width="431"></div>


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