# Adding a single variant to Curate

To add one or several variants, use manual entry in **Curate**. Follow the instructions below.

<figure><img src="/files/IGBs0YDZwnYLWDIDZogw" alt=""><figcaption><p>Adding a single variant to <strong>Curate</strong></p></figcaption></figure>

## How to add a variant in Curate

{% stepper %}
{% step %}
Open **Curate Variants**.
{% endstep %}

{% step %}
In the navigation panel, select the **Add new** button (<i class="fa-plus-large">:plus-large:</i> symbol).
{% endstep %}

{% step %}
In the **Add new variant** dialog, select the variant type:

* **SNV**: Single nucleotide variant or indel variant
* **CNV:** Deletion or duplication
  {% endstep %}

{% step %}
Enter variant details.

{% hint style="info" %}
Confirm the human genome reference (GRCh37 or GRCh38) in the navigation panel. The genome build must match the variant coordinates you enter in `Position`, `Position start`, and `Position end`.
{% endhint %}

**SNV variant details:**

<table><thead><tr><th valign="top">Field name</th><th>Expected input</th><th>Example</th></tr></thead><tbody><tr><td valign="top"><code>Chromosome</code></td><td><code>1</code> - <code>22</code>, <code>X</code>, <code>Y</code>, <code>M</code></td><td><code>X</code></td></tr><tr><td valign="top"><code>Position</code></td><td>Integer</td><td><code>123000</code></td></tr><tr><td valign="top"><code>REF</code></td><td><code>A</code>, <code>T</code>, <code>G</code>, <code>C</code>, or a string of these letters</td><td><code>G</code></td></tr><tr><td valign="top"><code>ALT</code></td><td><code>A</code>, <code>T</code>, <code>G</code>, <code>C</code>, or a string of these letters</td><td><code>GACT</code></td></tr></tbody></table>

**CNV variant details:**

<table><thead><tr><th valign="top">Field name</th><th>Expected input</th><th>Example</th></tr></thead><tbody><tr><td valign="top"><code>Chromosome</code></td><td><code>1</code> - <code>22</code>, <code>X</code>, <code>Y</code>, <code>M</code></td><td><code>14</code></td></tr><tr><td valign="top"><code>Position start</code></td><td>Integer</td><td><code>123000</code></td></tr><tr><td valign="top"><code>Position end</code></td><td>Integer. Must be greater than <code>Position start</code>.</td><td><code>124000</code></td></tr><tr><td valign="top"><code>REF</code></td><td><code>A</code>, <code>T</code>, <code>G</code>, <code>C</code>, or a string of these letters</td><td><code>G</code></td></tr><tr><td valign="top"><code>Type</code></td><td><code>DEL</code>, <code>DUP</code></td><td><code>DEL</code></td></tr></tbody></table>
{% endstep %}

{% step %}
Select **Add**.
{% endstep %}
{% endstepper %}

**Result:**

* Variant is added to **Curate**.
* The [**Curate Variant page**](/emedgene/emedgene-curate-manual/curate_variants/curate_variant_page.md) opens, where you can assign pathogenicity, add curated interpretation, select a disease, classify the variant using ACMG criteria, and perform additional actions as needed.

## Alternative ways to add variants to Curate

Unsure if manual variant entry in **Curate** is the right option?

* Upload a CSV file to efficiently handle a large set of variants. <i class="fa-up-right-from-square">:up-right-from-square:</i> [Learn more](/emedgene/emedgene-curate-manual/curate_variants/adding-variants-to-curate/adding-multiple-variants-to-curate.md)
* Export a variant directly from a case in **Analyze**. <i class="fa-up-right-from-square">:up-right-from-square:</i> [Learn more](/emedgene/emedgene-curate-manual/curate_variants/adding-variants-to-curate/exporting-a-variant-from-analyze.md)


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