Adding multiple variants to Curate

To add multiple variants to Curate, upload a CSV file containing variant information. Follow the instructions below.

Adding multiple variants to Curate

How to add a large set of variants in Curate

1

Prepare a CSV file with variant details. See CSV requirements.

2

Open Curate Variants.

3

Select Add new (plus-large symbol) in the navigation panel.

4

Select Switch to batch.

5

Confirm that the genome reference selected in the navigation panel (GRCh37 or GRCh38) matches the reference used in the CSV file.

6

Upload the CSV file.

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7

Review the file validation results:

  • If validation succeeds: Proceed to the next step (confirming file upload).

  • If validation fails:

    • Select Download the CSV file to download the CSV file with an added Error column detailing any issues.

    • Fix errors in either the original or annotated file. The Error column in the annotated CSV file is ignored during re-upload.

    • Select Cancel.

    • Return to the previous step (uploading the file).

    Select Download the CSV file to download your original file with an added Error column explaining the issue.
8

Select Upload to finalize the file upload.

9

After uploading the file to Curate, a notification appears with a Download report link. Download the upload summary file to review the status of each variant's upload.

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Upload results:

  • Success: Variant added with all details.

  • Partial success: Variant added but missing some details.

  • Duplication: Variant not added because it already exists in Curate.

  • Fail: Variant not added due to overlap or intergenic location.

Result: Variants may be added with all details, partially added, or not added. Review the upload summary to verify the status of each variant.

Alternative ways to add variants to Curate

  • Manually add a single or several variants by specifying their details. up-right-from-square Learn more

  • Export a variant directly from a case in Analyze. up-right-from-square Learn more

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