Adding multiple variants to Curate

To add multiple variants to Curate, upload a CSV file containing variant information. Follow the instructions below.

Adding multiple variants to Curate

How to add a large set of variants in Curate

1

Prepare a CSV file with variant details. See CSV requirements.

2

Open Curate Variants.

3

Select Add new ( symbol) in the navigation panel.

4

Select Switch to batch.

5

Confirm that the genome reference selected in the navigation panel (GRCh37 or GRCh38) matches the reference used in the CSV file.

6

Upload the CSV file.

Important: Do not leave the page until file upload is complete, as leaving will cancel the upload. The upload is finished when file validation results appear.

7

Review the file validation results:

• If validation succeeds: Proceed to the next step (confirming file upload).

• If validation fails:

  • Select Download the CSV file to download the CSV file with an added Error column detailing any issues.

  • Fix errors in either the original or annotated file. The Error column in the annotated CSV file is ignored during re-upload.

  • Select Cancel.

  • Return to the previous step (uploading the file).

  

  Select Download the CSV file to download your original file with an added Error column explaining the issue.

8

Select Upload to finalize the file upload.

9

After uploading the file to Curate, a notification appears with a Download report link. Download the upload summary file to review the status of each variant's upload.

Important: If you don't download the upload summary before closing the notification or leaving the page, it won’t be accessible later from the UI. You will need to contact Illumina Support for assistance.

Upload results:

• Success: Variant added with all details.

• Partial success: Variant added but missing some details.

• Duplication: Variant not added because it already exists in Curate.

• Fail: Variant not added due to overlap or intergenic location.

Result: Variants may be added with all details, partially added, or not added. Review the upload summary to verify the status of each variant.

Alternative ways to add variants to Curate

• Manually add a single or several variants by specifying their details. Learn more

• Export a variant directly from a case in Analyze. Learn more