> For the complete documentation index, see [llms.txt](https://help.connected.illumina.com/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://help.connected.illumina.com/emedgene/emedgene-curate-manual/curate_variants/adding-variants-to-curate/adding-or-updating-multiple-variants-in-curate.md).

# Adding or updating multiple variants in Curate

To add or update (v100.40.0+) multiple variants in **Curate**, upload a CSV[^1] file with variant information.

Follow the instructions below.

<figure><img src="/files/SB1pxGnDz4EHJrC067UA" alt=""><figcaption><p>Adding multiple variants to <strong>Curate</strong></p></figcaption></figure>

## How to add or update a large set of variants in Curate

{% stepper %}
{% step %}
Prepare a CSV file with variant details. See [CSV requirements](/emedgene/emedgene-curate-manual/curate_variants/adding-variants-to-curate/adding-or-updating-multiple-variants-in-curate/csv-format-requirements-for-variant-upload.md) for details about supported fields and formatting.

**Batch updates (v100.40.0+)**

Starting with v100.40.0, you can update existing variants in batch mode. To do this, include the **`Update`** column in the CSV file and set its value to `true` for each variant you want to update.
{% endstep %}

{% step %}
Open **Curate Variants**.
{% endstep %}

{% step %}
Select **Add new** (<i class="fa-plus-large">:plus-large:</i> symbol) in the navigation panel.
{% endstep %}

{% step %}
Select **Switch to batch**.
{% endstep %}

{% step %}
Confirm that the genome reference selected in the navigation panel (GRCh37 or GRCh38) matches the reference used in the CSV file.
{% endstep %}

{% step %}
Upload the CSV file.

{% hint style="warning" %}
**Important:** Do not leave the page until file upload is complete, as leaving will cancel the upload. The upload is finished when file validation results appear.
{% endhint %}
{% endstep %}

{% step %}
Review the file validation results:

* **If validation succeeds:** Proceed to the next step (confirming file upload).
* **If validation fails:**

  * Select **Download the CSV file** to download the CSV file with an added Error column detailing any issues.
  * Fix errors in either the original or annotated file. The Error column in the annotated CSV file is ignored during re-upload.
  * Select **Cancel**.
  * Return to the previous step (uploading the file).

  <figure><img src="/files/BTb3Mkt5h6OkeIu5arhP" alt=""><figcaption><p>Select <strong>Download the CSV file</strong> to download your original file with an added Error column explaining the issue.</p></figcaption></figure>

{% endstep %}

{% step %}
Select **Upload** to finalize the file upload.
{% endstep %}

{% step %}
After uploading the file to **Curate**, a notification appears with a **Download report** link. Download the upload summary file to review the status of each variant's upload.

{% hint style="warning" %}
**Important:** If you don't download the upload summary before closing the notification or leaving the page, it won’t be accessible later from the UI. You will need to contact Illumina Support for assistance.
{% endhint %}

**Upload results:**

* **Success:** Variant added with all details.
* **Partial success**: Variant added, but some fields were ignored.
* **Duplication**: Variant not added because it already exists in **Curate**.
* **Update**: Existing variant updated with new information.
* **Fail:** Variant not added due to overlap or intergenic location.

**Handling existing variants during batch upload**

* If **`Update`** is set to `false` (default), existing variant in **Curate** is marked as **Duplication** and is not updated.
* If **`Update`** is set to `true`, existing variant in **Curate** is updated with the new information from the CSV file.
  {% endstep %}
  {% endstepper %}

**Result:** Variants are added, partially added, updated, or skipped. Review the upload summary to confirm the outcome for each variant.

{% hint style="info" %}
**Note:** Updating existing variants with ACMG data does not change the ACMG schema version.
{% endhint %}

## Alternative ways to add variants to Curate

* Manually add a single or several variants by specifying their details. <i class="fa-up-right-from-square">:up-right-from-square:</i> [Learn more](/emedgene/emedgene-curate-manual/curate_variants/adding-variants-to-curate/adding-a-single-variant-to-curate.md)
* Export a variant directly from a case in **Analyze**. <i class="fa-up-right-from-square">:up-right-from-square:</i> [Learn more](/emedgene/emedgene-curate-manual/curate_variants/adding-variants-to-curate/exporting-a-variant-from-analyze.md)

[^1]: Comma-Separated Values


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