ACMG classification card

Card contents

The ACMG classification card on the Curate Variant page lets you apply ACMG evidence tags, review the resulting score and classification, and manage tag details for the variant.

This card appears only for small variants, not copy number variants.

Use it to:

• Review the overall ACMG classification and score, plus per-tag details such as question answers, strength, user notes, and manual update history
• Activate or inactivate ACMG evidence tags, modify tag strength, and update tag notes

ACMG classification card

ACMG score and classification calculation

The ACMG score and classification are calculated from the applied ACMG tags. When tags are added or updated, the card recalculates both values.

For SNV-specific ACMG logic, see Logic behind ACMG classification of SNVs and ACMG SNV criteria evaluation.

Outdated ACMG schema warning

When working in Curate, Emedgene keeps track of the ACMG schema version used to calculate the ACMG score for each curated variant.

Using an outdated schema may cause the classification to miss updated logic, use outdated strength definitions, or include tags that are no longer supported.

If the variant was curated using an older schema than the one currently active in Analyze, you’ll see a warning in the ACMG classification card. In that case you may want to review and update the classification, either directly on Curate Variant page or through the Update Curate action in Analyze.

ACMG data synchronization between Curate and Analyze

How Curate ACMG data appears in Analyze

ACMG tags stored in Curate are automatically applied in the ACMG SNV Classification wizard on the Variant page in Analyze. This includes:

• Tag status
• Answers to tag questions
• Tag strength
• Tag notes

ACMG classifications from Curate are marked with a Curate icon ().

How to update Curate ACMG data from Analyze

After reviewing ACMG data in Analyze, you can send updates back to Curate through the Update Curate action. This keeps ACMG annotations synchronized across Curate and Analyze.

ACMG data update traceability

The Activities panel on the Curate Variant page logs ACMG data changes made in Curate and through the Update Curate action in Analyze.

• Tag activation and inactivation, tag strength changes, and overall classification updates are logged with specific messages.
• Changes to tag notes and question answers are logged as a general update "Variant ACMG tags were updated".