> For the complete documentation index, see [llms.txt](https://help.connected.illumina.com/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://help.connected.illumina.com/emedgene/emedgene-curate-manual/curate_variants/curate_variant_page/top-bar.md).

# Header

## Header contents

The header of the [**Curate Variant page**](/emedgene/emedgene-curate-manual/curate_variants/curate_variant_page.md) shows the key identifying details of the variant and its current pathogenicity classification.

### Small variants

<figure><img src="https://1131024994-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FGCW0DnLlE7QjoZPNmKIi%2Fuploads%2Fgit-blob-bc72ffbe228597d286a967833b32e41632904470%2Fimage%20(167).png?alt=media" alt=""><figcaption><p><strong>Header of the Curate Variant page</strong> for a small variant.</p></figcaption></figure>

For small variants, including mtDNA variants, the header highlights:

* Clickable gene symbol linked to the gene page in [**Curate Genes**](/emedgene/emedgene-curate-manual/curate_genes_2_28.md)
* Variant type: `SNV`, `small ins`, or `small del`
* Genomic position and nucleotide change
* HGVS variant description
* [Main variant effect](/emedgene/emedgene-analyze-manual/tertiary-analysis-pipeline/how_does_emedgene_calculate_variant_effect_and_severity.md)
* Pathogenicity classification

### CNVs

<figure><img src="https://1131024994-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FGCW0DnLlE7QjoZPNmKIi%2Fuploads%2Fgit-blob-b1327b8c3476b0695d06e79354d37775cccad3c4%2Fimage%20(166).png?alt=media" alt=""><figcaption><p><strong>Header of the Curate Variant page</strong> for a copy number variant.</p></figcaption></figure>

For copy number variants, the header highlights:

* For each involved gene, a clickable gene symbol linked to the gene page in [**Curate Genes**](/emedgene/emedgene-curate-manual/curate_genes_2_28.md)
* Variant type: `DEL` or `DUP`
* Genomic range and variant length
* Pathogenicity classification

***

## How to update curated variant pathogenicity

{% stepper %}
{% step %}
In the header of the **Curate Variant page**, select **Pathogenicity**.
{% endstep %}

{% step %}
From the dropdown, select the classification you want to assign to the variant.
{% endstep %}
{% endstepper %}

**Result:** The pathogenicity classification is updated for the variant and used in future case annotations.


---

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