# Source of gnomAD data for small variants on GRCh38

\\\ Vira: very outdated information, needs rewriting

**Implementation for Emedgene pipeline version < v34.0:**

gnomAD data for GRCh38 exists for genomes only for version 3.1.

gnomAD exome data is only available for GRCh37 on previous versions.

To retain the wealth of exome data for GRCh38 users, the GRCh38 small variant gnomAD dataset integrates the following sources:

* Liftover of GRCh37 exome data from gnomAD v2 to GRCh38
* GRCh38 genome data from gnomAD v3

**Known limitation:**

This implementation contains some duplicate variants between v2 and v3.

**Implementation for Emedgene pipeline version** ≥ **v34.0:**

gnomAD has since released gnomAD v3.1.2 (non-v2) which includes only v3 variants that are not present in v2 and prevents duplication. Emedgene supports gnomAD v3.1.2 (non-v2) starting in Emedgene pipeline 34.0.


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