The Curate navigation panel is a vertical left-side panel that serves as a guide to the curated database.

It features (from top to bottom):

1. Home button

Clicking this deselects the variant you're looking at and brings you to the top of the variant table;

2. Human reference icon

Displays the currently selected reference genome. Upon clicking, you can change between GRCh37/hg19 and GRCh38/hg38 coordinates;

3. Add new variant/gene** button**

Launches the Add new data flow;

4. Variants button

Leads to the Curate Variant table;

5. Genes button

Leads to the Curate Gene table;

6. Articles button

🚧 under development;

7. Connection button

🚧 under development;

8. Emedgene Applications button

Opens the menu to allow you to switch back to Analyze from Curate;

9. User initialsor profile picture.

The Emedgene platform is divided into two applications:

• Analyze - the genomic analysis workbench,

• Curate - the knowledge management system.

To switch from Analyze to Curate:

Go to the nine-dot app launcher icon located on the left of the and select Curate from the dropdown menu.

To switch from Curate to Analyze:

Go to the nine-dot app launcher icon located on the Curate navigation panel and select Analyze from the dropdown menu.

Curate is Emedgene's knowledge management solution - a searchable, private database of variants manually curated by your team.

If you encounter a variant that is already in your Curate database, it will be highlighted in the Variant table and on the Variant page.

Curate will:

• save you time and effort to filter, prioritize and interpret variants,

• allow for variant interpretation consistency, and

• simplify variant reanalysis.

Note: To gain access to the Curate application, you will need the appropriate user roles. Additional roles are also required if you want permissions to export variants, create variants or update any information stored in Curate.

Curate supports both GRCh37/hg19 and GRCh38/hg38 genome assemblies. Each time the variant is added to the knowledge base, its genomic coordinates can be converted on-the-fly from one assembly to another. To change the genome assembly, click on the Human reference icon and select the genome assembly you wish to use.