Curate supports both GRCh37/hg19 and GRCh38/hg38 genome assemblies. Each time the variant is added to the knowledge base, its genomic coordinates can be converted on-the-fly from one assembly to another. To change the genome assembly, click on the Human reference icon and select the genome assembly you wish to use.

Curate is a knowledge management solution—a searchable, private database of variants curated by your team.

If you encounter a variant that is already in your Curate database, it will be highlighted in the Variant table and on the Variant page.

Curate:

• saves you time and effort to filter, prioritize and interpret variants

• allows for variant interpretation consistency

• simplifies variant reanalysis

Note: To gain access to the Curate application, you will need the appropriate . Additional roles are also required if you want permissions to export variants, create variants or update any information stored in Curate.

The Curate navigation panel is a vertical left-side panel that serves as a guide to the curated database.

It features (from top to bottom):

The Emedgene platform is divided into two applications:

• Analyze—the genomic analysis workbench

• Curate—the knowledge management system