# Adding a Variant Annotation Database

Click the **+ Add variant annotations** button under the *Variant annotations* section header on the [library file management page](broken://spaces/5WPPw051cYE3Zthy5U7m/pages/9npv9u7RcPWHiXftGkmn).

If you are using a human - hg38 assembly, variant annotation databases from various sources will appear in the *Variant annotation* drop-down list (Figure 1). Available variant annotation database sources include:

* dbSNP
* ClinVar
* gnomad
* Illumina DRAGEN haplotype

Multiple versions of the above databases are available. For human - hg38, only dbSNP and ClinVar is currently available. This list is periodically updated.

<div align="center"><figure><img src="/files/cjAHAVJKzQ1hAjkYTJoC" alt="" width="333"><figcaption><p align="center">Figure 1. For human - hg38, automatic downloads of various variant annotation databases are available from the Connected Multiomics repository.</p></figcaption></figure></div>

Choose a database from the drop-down list, select the **Download variant database** radio button and click **Create**.

If you prefer to add a custom variant annotation database, perhaps from another source or 'gold-standard' validated variants, choose **Add variant database** from the *Variant annotation* drop-down list (Figure 2). Name the variant annotation database by typing into the *Custom Name* box and click **Create**. Characters such as $ \* | \ : " < > ? / % cannot be used in custom names. A variant annotation database can be added from from your local computer by clicking the option of *My Computer*. Only the files with relevant file extensions will be visible (.vcf and various compressed formats).

<figure><img src="/files/wG9O2A19zGtyJgsBGNjy" alt=""><figcaption><p align="center">Figure 2. Add a custom variant annotation database</p></figcaption></figure>


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