> For the complete documentation index, see [llms.txt](https://help.connected.illumina.com/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://help.connected.illumina.com/icm/analyses/analysis-functionality/task-menu/biological-interpretation/correlation-engine-atlases.md).

# Correlation Engine atlases

The **Correlation Engine atlases** task is a biological interpretation tool that queries your differential analysis results against a set of atlases, enabling biological insights across multiple contexts. In Connected Multiomics, the **Correlation Engine atlases** task supports four atlases:

* *Body atlas*: queries for tissue, cell type, single cell relevant to your genes.
* *Disease atlas*: queries for diseases, traits, conditions, and surrogate endpoints associated with a gene.
* *Knockdown atlas*: queries for genetic perturbations (knockdown, knockout, or overexpression) affecting your gene, and how.
* *Pharmaco atlas*: queries for compounds and treatments significantly correlated to a gene, sequence region, biogroup, or bioset.

## Invoking Correlation Engine atlases

The **Correlation Engine atlases** task can be invoked from a differential analysis data node or a filtered feature list (e.g., filtered differential analysis result).

* Select a differential analysis data node or a filtered feature list data node.
* Under **Biological interpretation** menu section, select **Correlation Engine atlases**.
* Choose **Organism**, **Correlation Engine project**, and give a **name** to the Correlation Engine study, then click **Next**.

<figure><img src="/files/XPkgCr0UAKdw2iCmHo7H" alt=""><figcaption></figcaption></figure>

* Select a **Contrast** for the Correlation Engine analysis, choose a **feature identifier**, then click **Finish** to run the analysis.

<figure><img src="/files/Gk87P6ZqY3IFIrxJ9L1n" alt="" width="428"><figcaption></figcaption></figure>

## Correlation Engine atlases report

The Correlation Engine atlases task produces a task node and four data nodes - one for each atlas. Double-click on an atlas data node to view report.

<figure><img src="/files/wihJ87GqMABy98y4AcKz" alt="" width="322"><figcaption></figcaption></figure>

Atlas report opens into a data viewer with one or more result sheets, depending on the atlas. Each result sheet consists of a result table and a bar chart colored to reflect direction of regulation (blue for up, red for down). An example of knockdown atlas report is shown below, consisting of four result sheets, each for a different genetic perturbation.

<figure><img src="/files/j8HaPILpEsk5zVaBEbQF" alt=""><figcaption></figcaption></figure>


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