Correlation Engine atlases

The Correlation Engine atlases task is a biological interpretation tool that queries your differential analysis results against a set of atlases, enabling biological insights across multiple contexts. In Connected Multiomics, the Correlation Engine atlases task supports four atlases:

• Body atlas: queries for tissue, cell type, single cell relevant to your genes.

• Disease atlas: queries for diseases, traits, conditions, and surrogate endpoints associated with a gene.

• Knockdown atlas: queries for genetic perturbations (knockdown, knockout, or overexpression) affecting your gene, and how.

• Pharmaco atlas: queries for compounds and treatments significantly correlated to a gene, sequence region, biogroup, or bioset.

Invoking Correlation Engine atlases

The Correlation Engine atlases task can be invoked from a differential analysis data node or a filtered feature list (e.g., filtered differential analysis result).

• Select a differential analysis data node or a filtered feature list data node.

• Under Biological interpretation menu section, select Correlation Engine atlases.

• Choose Organism, Correlation Engine project, and give a name to the Correlation Engine study, then click Next.

• Select a Contrast for the Correlation Engine analysis, choose a feature identifier, then click Finish to run the analysis.

Correlation Engine atlases report

The Correlation Engine atlases task produces a task node and four data nodes - one for each atlas. Double-click on an atlas data node to view report.

Atlas report opens into a data viewer with one or more result sheets, depending on the atlas. Each result sheet consists of a result table and a bar chart colored to reflect direction of regulation (blue for up, red for down). An example of knockdown atlas report is shown below, consisting of four result sheets, each for a different genetic perturbation.