# Combine 5-base methylation and variant data
The *Combine 5-base methylation and variant data* task enables users to combine annotated differentially methylated regions (DMRs) and annotated variants, for dual-omics insights in DNA Methylation Prep data analysis.
## Running Combine 5-base methylation and variant data
The *Combine 5-base methylation and variant data* task expects annotated DMRs and annotated variants data within the same analysis. This task can be invoked at either *Annotated regions* data node or *Annotated variants* data node.
* Click **Annotated regions** or **Annotated variants** data node.
* Click **Combine multiomics data** section in the context-sensitive task menu.
* Click **Combine 5-base methylation and variant data**.
* Click **Select data node** to select another data node (*Annotated variants* or *Annotated regions*) for intersection or union.
* Data nodes that are selectable for combine are in blue. In example below, *Annotated regions* data node from the methylation analysis branch are selected.
* Select **intersection** or **union** to combine methylation and variant data, then click **Finish**.
* Intersection: Use gene ID to intersect DMRs and variants. Every intersected variant and DMR will be reported in an individual row in task report.
* Union: Report intersection (by gene ID) result and also variants that overlap DMR by specified distance (default is +/- 1000bp).
## Task output
When complete, double-click on **5-base methylation and variants** data node to open result. The task report is similar to the [Summarized cohort mutations](https://help.connected.illumina.com/icm/analyses/analysis-functionality/task-menu/variant-analysis/summarize-cohort-mutations) task report, with an additional column **Origin** to indicate if result in a row is present in both methylation and variant data (VC, DMR), or variant data only (VC), or methylation data only (DMR).
