# Generate methylation mvalues

This task is only available when a beta value matrix data node is selected. It is log2 ratio of methylated vs unmethylated signal.

Mvalues are preferred for statistical modeling because of their normal distribution. When perform this task, a new data node is generated which contains a matrix of mvalues.

In Connected Multiomics, it is not necessary to do this step separately when perform [Detected differential methylation](/icm/analyses/analysis-functionality/task-menu/statistics/detect-differential-methylation.md) on beta values, since this task automatically convert beta values to M values.


---

# Agent Instructions: Querying This Documentation

If you need additional information that is not directly available in this page, you can query the documentation dynamically by asking a question.

Perform an HTTP GET request on the current page URL with the `ask` query parameter:

```
GET https://help.connected.illumina.com/icm/analyses/analysis-functionality/task-menu/pre-analysis-tools/generate-methylation-mvalues.md?ask=<question>
```

The question should be specific, self-contained, and written in natural language.
The response will contain a direct answer to the question and relevant excerpts and sources from the documentation.

Use this mechanism when the answer is not explicitly present in the current page, you need clarification or additional context, or you want to retrieve related documentation sections.
