Custom Actionability Classification

Custom actionability classifications can be set up in Configuration. Later, when you create therapeutic, prognostic, and diagnostic assertions, you can specify these classifications.

Create custom actionability classifications as follows.

1. On the top toolbar, select Configuration.

2. In the General tab, select Actionability Classification. The default actionability classifications are based on AMP/ASCO/CAP Li et al, 2017. If you want to specify your own, select I want to classify using my own classifications.

3. Provide a name for the actionability classifications (for example, ESMO ESCAT).

4. Select Add.

5. Add a classification name (eg, Level 1).

6. [Optional] Add a description.

7. Choose a color.

8. Select Save.

9. Repeat steps 4–8 until you have your classification created.

   • Classifications can be deleted by selecting x on the created classification.

   • Classifications can be edited by selecting the pencil icon on the created classification.

10. Use the drag handles to map your classifications to the AMP/ASCO/CAP Li et al., 2017 guideline on the right side of the window. Place your classifications in order of their significance. After you create assertions, this order is used to prioritize variants and evidence.

    ❗ Whenever you edit these classifications, it does not modify existing assertions in your knowledge base or reports. When you encounter assertions using older classifications, they can be edited to use the latest classification.