# Variant Filters

The Variant Filters section describes how to add, configure, duplicate, or archive variant filters.

## Add and Configure a Variant Filter

1. On the top toolbar, select **Configuration**.
2. Select the **Test Components** tab.
3. Navigate to Variant Filters and select **New**.
4. Navigate to the Condition Group section and enter the applicable genes in the Genes field.
5. \[Optional] Select the **Include genes from diseases** check box.
6. Select **Apply**.
7. Select **Include** or **Exclude** from the drop-down list for each gene.
8. For Variant Category, select the field to open up a drop-down list of variants that can be included or excluded.
9. Select the check boxes next to the applicable variant types.
10. Select **Add Criteria** and select the applicable criteria from the drop-down list (for example, Cancer Hotspot Samples).
11. Select Include or Exclude from the drop-down list for the criteria.
12. To include or exclude additional criteria, repeat steps 10 and 11.
13. For AND or OR, select **Add Condition Group** to add any other applicable condition groups.
14. \[Optional] Select **Reset** to undo the changes to the condition groups.
15. Select **Save**.

> The Genomic Region criteria is not available when creating a filter from configuration but can be included when adding/editing filters in Variant grid . For more information, refer to [Add and Configure a Variant Filter](#add-and-configure-a-variant-filter).

## Edit a Variant Filter

1. On the top toolbar, **select Configuration**.
2. Select the **Test Components** tab.
3. For Variant Filters, select a filter.
4. Select **Edit**.
5. Update the applicable settings. For more information, refer to [Add and Configure a Variant Filter](#add-and-configure-a-variant-filter).
6. Select **Save**.

## Duplicate a Variant Filter

1. On the top toolbar, select **Configuration**.
2. Select the **Test Components** tab.
3. For Variant Filters, select the applicable filter.
4. In the right-hand pane, select **Duplicate**.
5. \[Optional] Adjust the condition group settings. For more information, refer to [Add and Configure a Variant Filter](#add-and-configure-a-variant-filter).
6. Select **Save**.

## Archive a Variant Filter

1. On the top toolbar, select **Configuration**.
2. Select the **Test Components** tab.
3. For Variant Filters, select the applicable filter.
4. In the right-hand pane, select **Archive**.
5. To confirm, select **Yes, change**.

## Default Filters

Connected Insights provides the following default filters to assist in preliminary test implementation:

| All Demo        | Filters for oncogenic, likely oncogenic, 1A, 1B, and 2C small variants, copy number variants, unidirectional gene fusions, and RNA splice variants. |
| --------------- | --------------------------------------------------------------------------------------------------------------------------------------------------- |
| SNV Demo        | Filters for oncogenic, likely oncogenic, 1A, 1B, and 2C small variants.                                                                             |
| CNV Demo        | Filters for oncogenic, likely oncogenic, 1A, 1B, and 2C copy number variants.                                                                       |
| SV Demo         | Filters for oncogenic, likely oncogenic, 1A, 1B, and 2C unidirectional gene fusions.                                                                |
| RNA Splice Demo | Filters for oncogenic, likely oncogenic, 1A, 1B, and 2C RNA splice variants.                                                                        |
| AML Demo        | Filters for AML-related variants based on WHO 2022 and ELN 2022 guidelines.                                                                         |