Case Details

The Case Details pane contains the following tabs:

• Summary

• Related Cases

• Activity (Connected Insights - Local only)

Select a case, and then select Case Details to open the Case Details pane.

Summary Tab

The Summary tab contains the following information:

• Case ID — Indicates the unique ID for the case.

• Workflow — Indicates the type of analysis available for the case. The workflow name is defined at the user level.

• Genome — Indicates the genome build for the case.

• Workflow Type — Indicates the type of analysis for this case: DNA, RNA, or DNA + RNA.

• Sex — The biological sex of the sample subject: male, female, or unknown.

• Disease — The disease associated with the case. Connected Insights allows you to edit this detail. When you change the disease, the case is reprocessed. Any assertions that were made before changing the disease are removed from the report.

• Test Definition — The set of default parameters applied to a case when ingested into the platform.

• Tags — Helps with organization cases based on free text terms that can be used with the Search function.

• Participants — Users in the workgroup that are assigned to the case.

If the case disease is Acute Myeloid Leukemia or a subtype, the following fields are available and are used for Classification & Risk Stratification Prediction:

• Blast Count % - Indicates the blast count %. Acceptable values are positive integers.

• History of Cytotoxic Therapy Exposure - Indicates if the subject has history of cytotoxic therapy exposure. Acceptable values are Yes, No, and Unknown.

• History of Myelodysplastic Syndrome - Indicates if the subject has history of myelodysplastic syndrome. Acceptable values are Yes, No, and Unknown.

• History of Myeloproliferative Neoplasm - Indicates if the subject has history of myeloproliferative neoplasm. Acceptable values are Yes, No, and Unknown.

Related Cases Tab

Use the Related Cases tab to do the following actions:

• Edit and open cases in the Case Timeline

• For Connected Insights - Local, download log files

• Change the case subject

• Merge cases For more information on merging cases, refer to Merge Cases.
• Change the Case Subject

  1. In the Case Details pane, select the Related Cases tab.

  2. Select the pencil icon next to Subject.

  3. In the Subject field, type a subject ID (for example, A).

  4. To confirm the subject change, select Confirm.

Download Log Files

1. In the Case Details pane, select the Activity tab.

2. Select Download Log Files for this Case.

The ZIP file that is downloaded includes the system technical application log files, data upload logs and case analysis logs. If there is an issue with Connected Insights or you cannot upload case data, these files can be sent to Illumina Technical Support for troubleshooting.

Edit Custom Case Data

1. In the Case Details pane, select Edit Case. All available fields accessible for editing are displayed.

2. Edit or add information about each subject detail.

3. [Optional] Edit the Disease case detail as follows. a. Under Subject, navigate to the Disease field. b. Enter a disease name. When the tumor type is unknown, "Malignant neoplastic disease (SNOMEDCT: 363346000)" or "Malignant tumor of unknown origin (SNOMEDCT: 255052006)" can be used. However, the accuracy of actionability will be higher the more specific the tumor type provided is. c. When prompted to confirm that you want to change the disease, select Yes, Continue Saving.

4. [Optional] Add tags to a case or remove them as follows. a. Under Case, navigate to the Tags field. b. Type a tag name and press Enter. c. To remove a tag from a case, select the X next to the tag name. d. To search for or add tags from the Cases page, select the + under the Tags column and enter the tag name. Remove the tag by selecting the X next to the name.

5. After editing the case details, select Save.

Any restricted custom case data fields are hidden in the case details. These fields are replaced with asterisks. When editing custom case data, the fields are displayed for editing and only a user with lab director permissions can edit, show, or hide these fields. When viewing the draft report, restricted fields are hidden for restricted users and displayed for privileged users.

Reanalyze Case (Connected Insights - Local only)

Reanalyze case action allows you to reanalzye a case that has previously failed. Processing failure could be due to any of the following error conditions:

• External storage drive is not accessible or permission have been altered.

• Required space is not available on external storage or in /staging (on the DRAGEN server v4) to process a case.

• External storage drive read or write issue due to low or interrupted network bandwidth.

For the reanalysis to succeed, all the required molecular data must be available. To reanalyze a case that failed with a "Has Issues" status, follow below:

1. Open the case from the Cases page.

2. Click Case Details in the top-right.

3. In the Case Details pane, select Reanalyze Case.

4. Confirm within the pop up.

5. The case will be submitted for processing with the available molecular data and existing configuration.