Illumina Connected Insights is a software solution that enables tertiary analysis of next-generation sequencing (NGS) data. There are two versions of Illumina Connected Insights:
Connected Insights - Cloud—This version is hosted by Illumina.
Connected Insights - Local—This version is installed on the local DRAGEN server v4. Both versions of Illumina Connected Insights have the same functionality, but Connected Insights - Local has differences in installation, administration, and license management due to the method of deployment.
In the current version, Connected Insights enables tertiary analysis of variant data generated using somatic oncology assays. The software accepts data generated from DNA and RNA sequencing workflows and can be configured to accept input data from oncology assays and variant callers. Connected Insights integrates several genomic databases that are used to annotate uploaded data to help understand its biological significance.
The software supports variants frequently identified in tumor samples (for example, SNVs, insertions, deletions, fusions, and structural variants). The software also accepts and enables user interpretation for genome-wide biomarkers (for example, tumor mutational burden (TMB), microsatellite instability (MSI), and genomic instability score (GIS) used to assess homologous recombination deficiency (HRD)).
The software has the following features:
Automated upload of secondary analysis files and case creation
Case management
Annotation of genes and variants using connected databases
Storage of variant interpretation records (assertions) produced by the user
Configurable test definitions
Customizable gene and variant filters
Visualization of variant information
Generation and editing of summary reports
The following illustration shows typical data flow in Connected Insights - Local
Below is illustration of network interaction of Connected Insights - Local
