The Biological Classification section of the Biomarker Details page summarizes all biological assertions previously created for the variant across all sources (i.e., My Knowledge Base, OncoKB, CKB).
If you have existing knowledge to upload to the system, refer to Upload Assertions.
You can filter assertions by source, diseases, and summary. Filter changes are saved and applied across variants within a case and can be reset if needed.
Field Name
Description
Directional Arrows
Opens to view the assertion summary.
Update Date
The last date that the assertion was updated.
Biomarker
Indicates how the assertion is related to the variant (for example, specific amino acid change or specific exon change).
HRD
Indicates whether an assertion is associated with HRD positive or negative. This column is available for GIS and variants when the selected transcript is for BRCA1/2.
Classification
This column displays the classification as indicated by the knowledge base.
Type
The assertion type (for example, biological). For more information, refer to Interpret a Variant.
Disease
The disease associated with the classification.
Actions
This column contains the following available actions: • Add to report • Archive, if the assertion is in My Knowledge Base • Copy to New Assertion, if the assertion is not in My Knowledge Base • View past cases
When reporting an assertion that is not from My Knowledge Base (e.g., OncoKB), classifications are reported with the following adjustments:
Connected Insights
OncoKB
Oncogenic
Oncogenic
Likely Oncogenic
Likely Oncogenic
Uncertain Significance
Inconclusive
Likely Benign
Likely Neutral
Resistance
Resistance
Connected Insights provides the Memorial Sloan Kettering OncoKB. For more information, refer to the OncoKB website.
The following from OncoKB is not supported:
Non-compliant HGVS
Unspecified positions: Epigenetic Silencing, ARv567es, AR-V7, DNMT3B7, vIII, vII, vV, TGFBR1*6A, Overexpression, Wildtype, Promoter Hypermethylation, Hypermethylation, Kinase Domain Duplication, Internal Tandem Duplication, Partial Tandem Duplication
Connected Insights provides the Genomenon Cancer Knowledge Base (formerly Jackson Laboratory Clinical Knowledge Base). For more information, refer to the Genomenon CKB website.
The following from CKB is not supported:
Complex molecular profiles (for example, co-occuring biomarker assertions)
Emerging and risk factor evidence types
Class #, over exp, dec exp, hypermethylation, hypomethylation, dup exonX, dup exonX-X, LOH, loss, negative (except for HRD andMSI), positive (except for HRD), and wild type variants.
To edit an assertion, add it to the report before editing. For more information, refer to .
Oncogenic
Oncogenic
Likely Oncogenic
Likely Oncogenic
Uncertain Significance
Inconclusive
Likely Benign
Likely Neutral
Resistance
Resistance