# Release Notes To install or upgrade to the latest version of Partek Genomics Suite software, follow the directions outlined in the [Installation Guide](https://github.com/illumina-swi/partek-docs/blob/main/display/PGS/Installation+Guide/README.md). ## PGS7.21.1119 Bug fixes: * Support MacOS 12 * Minor bug fixes ## PGS7.20.0831 Bug fixes: * Minor bug fixes ## PGS7.19.1125 Bug fixes: * Improved memory efficiency * Minor bug fixes ## PGS7.18.0723 General Improvement: * Microarray methylation workflow to make it more intuitive Bug fixes: * Minor bug fixes ## PGS7.18.0518 General Improvement: * Implemented DMRCate algorithm for differential methylated regions detection * Added false discovery rate report in html format * Add options to delete rows contains missing value only during text import Bug fixes: * Minor bug fixes ## PGS7.18.0402 General Improvement: * Sped up multidimensional scaling function * Added chi-square analysis for categorical data * Improved Fisher exact test on integer columns with two distinct values * Improved handling beta value as 0 or 1 during M value transformation, instead of output "?", we set the value as 1e-6 or 9e-6 by default Bug fixes: * Fixed GEO downloader issue * Fixed scatterplot set cutoff line and regression line button issue * Fixed a dot plot close issue * Bug fixes on OSX ## PGS7.18.0130 General Improvement: * Improved the methylation workflow – add region methylation analysis workflow * Added correlation analysis across two spreadsheets when they have the same set of samples Bug fixes: * Bug fixes on OSX ## PGS7.17.1222 General Improvement: * Improved the ANOVA contrast dialog; added the option to output difference between the two groups instead of fold change * Added new options on the Illumina methylation array importer to allow filtering of probes based on detection p-value and XY chromosomes * Improved Illumina methylation array analysis workflow to compute differential methylation sites based on M value and report the difference of M and beta values Bug fixes: * Fix Tk event crashes on OSX * Other minor bug fixes ## PGS7.17.1103 General Improvement: * Sped up genome view with large annotation files * Added option to specify output file name on task dialogs * Added option to save merged spreadsheet to a new spreadsheet Bug fixes: * Fixed a hierarchical clustering viewer bug on Mac version * Other minor bug fixes ## PGS7.17.1018 General Improvement: * Partek spreadsheet can only be saved as binary format * Partek spreadsheet can be exported as text format. The name of the exported spreadsheet will not be changed * "Import Text File" will not change the input text file, the imported file will be saved as user-defined name in binary format * When there are unsaved spreadsheets, "Save Project..." and "Export Zipped Project..." will give a warning message to save each unsaved spreadsheet * When cloning a spreadsheet, the newly generated spreadsheet name is unique by default * Re-ordered the File menu to improve usability * Added a function to impute missing values with random numbers from a defined distribution * Improved the "Save Image As..." dialog on Mac and Linux * Added support for save image as JPEG on Mac and Linux * Added file type selector for open and save file dialogs on Mac * Violin Plot displays the properties tab by default * Gene Expression workflow "Import from Affymetrix CEL Files" and File menu "Import Affymetrix .CEL Files" produce the same output spreadsheet for gene expression arrays * Improved graphics for visualizations on Mac Bug fixes: * Fixed a bug on "Split Column" dialog on Mac * Fixed a bug in "Import Affymetrix .ARR File..." * Other minor bug fixes ## PGS7.17.0918 General Improvement: * Most of the computations are multi-threaded, which drastically increases the speed * Viewers generated from spreadsheets are new tabs within the same window frame by default; viewer windows can be docked back to the main window frame * Workflow panel is visible in any invoked viewers, order of the workflow steps is more intuitive * Updated with modern icons and graphics color palette * Mixed model ANOVA uses REML by default * Sample ID factor is not included in the model of Alt-splicing ANOVA, GO ANOVA, pathway ANOVA * Apply button are removed from most of the dialogs * Improved interface is cleaner and more user friendly * New functional normalization method in the Illumina methylation array importer (450K and 850K) * Improved SWAN normalization in the Illumina methylation array importer * Allows import of different versions of the Illumina methylation arrays when using the same set of library files * Improved text file importer by adding wizard for specifying the properties of the spreadsheet * Removed repeated measures menu option, it is recommended to use ANOVA doing repeated measures analysis * Simplified menus and dialogs, removed obsolete functions, improved wording * Automatically downloads annotation files, even from sites with HTTPS or redirects (e.g. Affymetrix and GEO) * Logged data is detected and appropriate defaults are automatically set Older release notes are available on our website at [Partek® Genomics Suite™ Software Update Archive](http://www.partek.com/updates-archive).