The Polymorphism Filters enable filtering variants by alternative allele frequencies and genotype counts in public and internal databases. The filters can operate in a Simple or Advanced mode.
Switch on or off Display Polymorphism option:
When switched on, no restrictions are being applied.
When switched off, variants with allele frequency >0.05 in public databases or >0.25 in the EmedgeneDB are filtered out.
Filter variant list by limiting the maximum Allele Frequency, Hom/Hemi and Het counts in one of the public database options (GnomAD, ExAC, 1000 Genomes, or GME) or, by default, in all (All Databases). The default values for Hom/Hemi and Het can be exceeded using the text box.
In addition, limit results by the maximum Allele Frequency in internal databases:
Emedgene Database - a static sample set of 806 healthy individuals. Aimed at getting rid of the artifacts generated by our FASTQ processing pipeline
Organization Databases, e.g., NoiseDB - a blacklist of variants (implemented by request).
When Filters are Reset to Default, The Polymorphism Filters are set to the Display Polymorphism option of the Simple mode, i.e., no filtering.