Software Billing

Illumina software usage is measured in two ways:

• iCredits: Used for data analysis, computation, storage, and transfer.

• Samples: Used for interpreting sequenced samples. Different types exist based on the software and use case, such as:

  • Emedgene Genomic Equivalent Samples

  • Emedgene Array Samples

  • Illumina Connected Insights Genomic Equivalent Samples

Ensure you purchase the correct samples for your workflow requirements.

Illumina software products and usage pricing overview

Below are the Illumina software products and their software usage pricing details:

Illumina Connected Analytics

Illumina Connected Analytics (ICA) is a cloud-based platform for multi-omics data management and analysis. Charges for storage and compute workloads are in iCredits. For pricing details, visit the ICA Pricing page.

BaseSpace Sequence Hub

BaseSpace Sequence Hub provides genomic data analysis, storage, and sharing. It supports apps for alignment, variant calling, and data visualization. Costs for storage, compute, and apps are in iCredits. For pricing details, visit BaseSpace Pricing page.

Illumina Connected Multiomics

Illumina Connected Multiomics (ICM) is a cloud platform for biologists and bioinformaticians to analyze multiomics data efficiently. It organizes data into studies, applies statistical methods, references biological databases, correlates results across data types, and offers visualization tools for interpretation. Costs for this streamlined data analysis are in iCredits. For pricing details, visit ICM Pricing page.

Illumina Connected Insights

Illumina Connected Insights (ICI) is a robust software for interpreting and reporting NGS data. It processes DNA and RNA oncology assay data, supporting common tumor variants like SNVs, indels, CNVs, SVs, fusions, and splice variants, as well as biomarkers such as TMB, MSI, and GIS for HRD assessment. By integrating with multiple genomic databases, it provides biological insights and creates tailored summary reports.

There are two ways to access Connected Insights:

• Cloud - Costs for cloud analysis are charged in Genomic Samples (GEs) and costs for data storage on ICA are charged in iCredits.

• Local - Costs for local analysis via DRAGEN Server are charged in GEs.

For pricing details, visit ICI Pricing page.

Emedgene

Emedgene unlocks genomic insights for hereditary disease and streamline your tertiary analysis workflows. The Emedgene platform is divided into two applications:

• Analyze - Genomic analysis workbench, where you can accession, interpret, curate and report on your cases, while also efficiently managing the lab workflow

• Curate - A repository for all of your organizational curated knowledge

Costs for this analysis are in Genomic Samples(GEs).

Billing Model Overview

Platform Usage

All software usage is eligible for charging. This includes any compute, storage, data transfer, or other metered activity associated with your account.

We recommend that you regularly review your usage and understand how costs accrue, both in one-time costs, such as compute events, or ongoing, such as storage. You are responsible for stopping usage and deleting any data/storage you no longer want to pay for.

Billing is usage‑based: if resources continue running or data remains stored on the platform, costs continue to accrue. To avoid charges, please shut down usage and remove data you no longer need.

Usage Tracking

The Usage Explorer is your central tool for managing and optimizing software consumption at Illumina. It helps you to:

Monitor Usage in Real Time

• Track how iCredits or samples are consumed across various products and projects.

Manage Billing Balances

• Easily view Pre-Funded and Post-Paid balances at a glance to always stay informed.

Audit and Forecast

• Access detailed monthly usage statements.

• Generate custom usage reports to analyze trends, forecast future needs, and prevent unexpected costs.

Optimize Behavior

• Identify high-usage patterns and adjust workflows to remain within budget.

How software usage is billed

Software usage requires a subscription and can be billed through either monthly invoicing or pre-funded credits. Software usage differs based on software products and usage types.

iCredits Billing

We offer two billing options for iCredits.

1. Post-Paid (Monthly Invoicing) Billing:

• You pay for usage after the occurs, billing is in monthly arrears.

• This is the default billing method.

• Invoices are sent to the Bill‑To contact on your account—typically your organization’s Finance or Accounts Payable team, or another designated recipient. Some customers also receive invoices through portals like Ariba or Coupa, depending on their setup. If you need to update the Bill‑To contact or add additional recipients, Support/Customer Care can assist.

• If you do not purchase or contract any pre-funded iCredits in advance, your usage will be billed automatically at the end of the month.

• If your pre-funded iCredits run out (balance reaches zero), billing will switch to post-paid automatically.

2. Pre-Funded Billing:

You purchase or contract for iCredits in advance and draw down from your balance as you use them. There are two ways to pre-fund.

• Pre-paid iCredits

  • You purchase a fixed amount of iCredits upfront. To view purchasing options for iCredits click here

  • Usage reduces your balance until it reaches zero.

  • Before your balance runs out, you’ll need to buy more iCredits or your account will switch to Post-Paid billing automatically.

• Open Purchase Order iCredits

  • You contract for a set quantity of iCredits with an expiration date. To view purchasing options for iCredits click here

  • A new Open Purchase Order is required when:

    • The allocated quantity is used up, or

    • The contract expires, whichever happens first.

  • Early renewal ensures uninterrupted pre-funded billing.

Important: Any iCredit usage beyond your Pre-Funded balance will be billed automatically.

See an Example for Pre-funded billing

You purchase and register 1,000 worth of pre-paid iCredits before March 1. If you use 800 by mid-month, your remaining balance is 200. Based on your average usage, you’ll likely need to buy additional pre-paid iCredits before the billing period ends (March 31). If your balance reaches zero, any further usage will automatically switch to post-paid billing.

See an Example for Post-paid billing

If you start the month with no pre-funded iCredits, all usage for March will appear on your April invoice. If you begin with $500 in pre-funded iCredits and use them up mid-month, any additional usage will be billed post-paid on your next invoice.

See an example for Open PO billing

You contract an Open Purchase Order for 10,000 iCredits with an expiration date of June 30. If you use all 10,000 iCredits by May 15, you’ll need to create a new PO to continue using pre-funded billing. If June 30 arrives and the contract expires with unused iCredits, you’ll need to renew or contract a new PO to stay on pre-funded billing. In either case—whether the iCredits are depleted or the contract expires—any additional usage after that point will automatically switch to post-paid billing.

Sample Billing

Only available through pre-funded billing.

• Pre-paid Samples

  • You purchase a fixed amount of Samples upfront.

  • Usage draws down from your balance until it reaches zero.

  • When your balance runs out, you’ll need to purchase additional Samples to continue usage.

Post-Paid iCredit Billing + Pre-Paid Sample Billing

When your account uses iCredits (Post‑Paid / Monthly Invoicing) and Prepaid Samples together, your usage is billed in two parallel streams, depending on the product type.

• Usage Explorer

  • A unified view of your overall software usage.

  • Balances:

    • iCredits (Post‑Paid): Shows estimated month‑to‑date charges that will appear on your monthly invoice.

    • Samples (Prepaid): Shows your remaining Sample balance and the usage drawdown for Sample-based products.

• End‑of‑month invoice

  • iCredits: All usage metered via iCredits for the previous month will be billed in arrears

  • Samples: There is no invoice for Sample usage.

Tip: Each product clearly indicates whether it consumes iCredits or Samples in its usage details, so you can trace charges and drawdowns back to the source.

See an example for Post-Paid iCredit Billing + Pre-Paid Sample Billing

Example A — Both consumables in play

• You run a pipeline that uses iCredits and a separate workflow that uses Samples.

• Mid‑month, your Samples drop from 200 to 0; your iCredit accrued charges continue to grow.

• Result:

  • iCredits: You’ll see the total on your next invoice (post‑paid).

  • Samples: You will need to buy more Samples.

Example B — Buying more Samples

• You purchase Prepaid Samples.

• Result:

  • Your Sample balance updates immediately and future Sample‑metered usage draws down from that balance.

  • The Sample purchase appears as a prepaid transaction (not as post‑paid usage).

How transitioning between billing options works

Illumina is flexible in moving between billing options. Below are the rules to how transitioning between billing options works:

iCredits Billing Options

New Customers

• Automatically assigned to Post-Paid billing.

• To switch to Pre-Funded billing, purchase Pre-Paid or contract Open Purchase Order iCredits before using Illumina software.

• Any usage before Pre-Funded iCredits are purchased/contracted and registered will be Post-Paid billed.

Existing Customers

• Automatically move to Post-Paid billing if Pre-Funded iCredits are depleted.

• Can move back to Pre-Funded billing by make another purchase or contract.

Depletion of Pre-Funded iCredits results in automatic switch to Post-Paid billing.

Samples Billing

• Available only through Pre-Funded billing.

• New and existing customers must purchase Pre-Paid Samples in order to use Illumina software products that consume Samples.

Notifications & Alerts

Illumina provides a range of automated notifications to help users effectively manage their usage and billing, focusing on low balances, threshold alerts, and invoice triggers.

Usage Explorer Usage Notifications

• iCredit Monthly Budget Alerts: Notifications are sent when your configured monthly budget threshold is reached, allowing you to monitor spending and take action before exceeding your planned usage. You can set up or adjust your monthly budget notification at any time in Usage Explorer.

iCredit Pre-Funded Billing Notifications

• Low Balance Alerts: Notifications are sent when both Pre-Paid and contracted Open Purchase Order iCredit balances are low.

iCredit Post-Funded Billing Notifications

• End of Billing Period Alerts: Invoices are sent at the end of each billing cycle.

Sample Post-Funded Billing Notifications

• Sample notifications are planned for release in the upcoming year.

This system ensures users can stay informed and proactive in managing their financial commitments efficiently.

How to avoid unintended charges

Before Your Subscription Expires:

• Review active resources (workflows, pipelines, jobs) and stop anything you no longer need.

• Delete storage and any temporary data you don’t want to keep.

• Download or export anything you need to retain off‑platform.

After Your Subscription Expires:

• Billing for any remaining usage (e.g., stored data you did not delete) continues according to your billing option.

• If your subscription is expired and you cannot access the product to delete storage or shut down usage, contact Support/Customer Care using the contact information at the bottom of this page. We will help restore access so you can remove data and prevent further charges.

Important: If you do not reach out and your data remains on the platform, usage charges will continue.

See an Example for Storage left after iCredits expiry

Your subscription ends on March 31, but you keep 2 TB of data in storage. Until you delete that data, storage usage continues to accrue and will be billed on your next monthly invoice.

Best Practices to Avoid Unwanted Charges

• Set alerts in Usage Explorer.

• Schedule a pre‑expiry cleanup: shut down jobs and delete storage you don’t need.

• Use project tags/labels to find and remove old or orphaned resources quickly.

• Review Usage Explorer weekly to catch unexpected activity.

Summary

• Illumina software usage is billed through: iCredits and Samples.

• iCredits support post-paid (monthly invoicing) or pre-funded billing.

• Samples are pre-funded only.

• If pre-funded iCredits are depleted, billing switches to post-paid automatically.

• Use Usage Explorer to monitor usage, balances, and forecast spend.

Help and Support

For customer service inquiries, email: [email protected]

Visit our website at: www.illumina.com