Manage Assertions
My Knowledge Base is a private database where all created assertions are stored.
Users can view, edit, collaborate on, archive/unarchive, track changes, and view reports for assertions.
Viewing Assertions
Access all My Knowledge Base assertions via My Knowledge Base using the app selector (grid icon) in the top-right.
Explore variant interpretations, gene descriptions, and other assertions under respective tabs.
Apply filters for specific searches and click the arrow on the left side of the assertion for details information and history.
To download assertions, select + New Assertion and then Download to view.
Editing Assertions
Edit My Knowledge Base assertions directly on the Biomarker Details page within a case or through My Knowledge Base.
Update necessary fields and set the approval status to Draft, Pending Approval, or Approved.
Refer to Interpret a Variant, Create Clinical Trials, or Create Gene Descriptions for field descriptions.
Assertion Collaboration
Use assertion statuses to manage the collaborative approval process.
Draft: For incomplete interpretations or those created by users without approval rights (i.e., case manager - curator).
Pending Approval: When assertions are ready for review.
Approved: After assertions have been reviewed and confirmed.
Archived: To remove assertions from active use while keeping them for records.
Reporting Unapproved Assertions
A report cannot be approved if reported assertions have statuses Draft, Pending Approval, or Archived.
If a reported assertion has Draft or Pending Approval status, an icon accompanies the assertion on key pages. A figure below shows a draft assertion in the Overview page, Biomarker Details page and in the assertion form.
Archiving Assertions
Archiving is used to remove My Knowledge Base assertions from active use while keeping them for records. Archived assertions are not displayed in the Overview, Variants, and Biomarker Details pages, and cannot be added to the report.
To archive an assertion while working on a specific case:
Find a My Knowledge Base assertion on the Biomarker Details page.
Select Archive in the menu to the left of "Report".
To archive an assertion outside of a specific case:
Navigate to My Knowledge Base using the app selector (grid icon) in the top-right.
Find the assertion you want to archive by searching or filtering.
Select Archive in the menu on the right side.
To unarchive an assertion:
Navigate to My Knowledge Base using the app selector (grid icon) in the top-right.
Find the archived assertion you want to unarchive by searching or filtering.
Select Unarchive in the menu on the right.
Roles and Permissions
Case Manager - Curator can assign all statuses, except for approved and archived.
Case Manager can assign all statuses, except for archived.
Lab Director can assign all statuses.
Administrator (Connected Insights - Local) can assign all statuses.
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