Clinical Trials

Clinical trials are listed in this when one of the knowledge bases determines the trial to be a match for the variant. The information in this table is from the clinical trial database.

By default, the assertions are filtered by the case and ancestor diseases. Ancestor diseases are determined using SNOMEDCT. These diseases can be viewed at the SNOMED CT Browser website, with the following exceptions:

• Descendents of neoplastic disease do not include ancestors beyond neoplastic disease.

• Non-small cell lung cancer has been added as an ancestor of adenocarcinoma of lung.

You can also filter by other diseases, title, city, state, and country.

Filter changes are saved and applied across variants within a case and can be reset if needed.

Clinical Trials Legend

Field Name	Description
Column	Description
Update Date	The last date that the assertion was updated.
Source	Knowledge base origin of the clinical trial.
Status	Indicates the TMB, MSI, or GIS status for the clinical trial. This column is available for TMB, MSI,and GIS.
HRD	Indicates whether a clinical trial is associated with HRD positive or negative. This column is available for GIS and variants, when the selected transcript is for BRCA1/2.
Biomarker	Indicates how the assertion is related to the variant (for example, specific amino acid change or specific exon change).
Title	Title of the clinical trial.
Phase	Phase of the clinical trial.
Location	Location of the clinical trial.
Disease	Disease for the clinical trial.
Actions	This column contains the following available actions: • Select the hyperlink to display the full listing about the trial in a new browser tab. • Add to report • Archive, if the assertion is in My Knowledge Base • Copy to New Assertion, if the assertion is not in My Knowledge Base • View past cases To edit an assertion, add it to the report before editing. For more information, refer to Manage Assertions.

Available Clinical Trials Knowledge Bases

Connected Insights provides access to the National Library of Medicine Clinical Trials website, which provides information on publicly and privately supported clinical studies on a wide range of diseases and conditions.

The following from JAX-CKB are not currently supported:

• Clinical trials with a recruitment status of completed, withdrawn, or active, not recruiting.

• Variants that have the excluded requirement type.

The software does not yet determine if a case has all the requirements for a clinical trial (for example, a clinical trial requires two variants).