> For the complete documentation index, see [llms.txt](https://help.connected.illumina.com/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://help.connected.illumina.com/emedgene/emedgene-curate-manual/curate_variants/curate_variant_page.md).
# Curate Variant page
The **Curate Variant page** presents the most clinically relevant variant information.
## Components of the Curate Variant page
### Top bar
that lists:
* Gene symbol. When clicked, the software directs you to [**Curate Genes**](/emedgene/emedgene-curate-manual/curate_genes_2_28.md).
* HGVS descriptions for genomic DNA, coding DNA, and protein-level changes
* Variant effect
* [Pathogenicity](/emedgene/emedgene-analyze-manual/variant_page/evidence_section.md).
You can change **Pathogenicity** by selecting a different option from the **dropdown menu.**
***
### Interpretation card
that features:
* The **Curated** tab intended to be used for your curated variant interpretation. This text can be reused in the [Variant Interpretation notes](/emedgene/emedgene-analyze-manual/variant_page/evidence_section.md) within a case
* The **Note** tab for your draft notes on the variant
To edit your notes, select the tab (**Curated** or **Note**), and press the **Edit** button. Edit the text and apply the formatting. Don't forget to click **Save**!
***
### Gene's related diseases card
that includes:
* The number of gene-associated diseases as reported in OMIM, ORPHANET, CGD, ClinVar, and academic papers included in the Emedgene knowledge graph
* The currently selected condition
* Links to data sources
* Inheritance mode icons where available
* A **Change** button that opens the disease selection menu
***
### Variant information card
that highlights:
* The type of variant
* Main effect relevant to the selected transcript
* Gene symbol
* HGVS format for coding and protein levels changes
You may select a different reference transcript from the dropdown menu.
To copy the HGVS descriptions in the clipboard, click the **copy icon** on the right.
***
### ACMG Classification card
The ACMG Classification system in Emedgene supports a streamlined and flexible workflow across **Analyze** and **Curate**, allowing users to apply, manage, and reuse ACMG evaluations more effectively. Whether you're annotating a new variant or updating existing records, the tools available help maintain traceable and consistent variant interpretations.
#### Storing and managing ACMG classifications in Curate
You can store ACMG classification tags within **Curate**, enabling automated or manual application of ACMG logic to variants. This supports both new **Curate** entries and updates to existing ones.
Stored ACMG tags in **Curate** include classification logic, tag strength, tag-specific notes, and scores.
ACMG tags in **Curate** can be edited by users with the appropriate role and viewed (but not changed) by other users.
Whenever tags are added or modified, the system automatically recalculates the overall pathogenicity classification and score.
All changes to ACMG tags—including activation/inactivation, tag strength adjustments, and classification updates—are logged under **Activities > Curate ACMG.**
{% hint style="info" %}
Changes to ACMG notes are not recorded in the activity log.
{% endhint %}
**How stored classifications are applied in Analyze**
When analyzing a case that contains variants with ACMG tags stored in **Curate**:
* The existing ACMG classification is automatically applied to variants tagged by **AI Shortlist**.
* This includes consideration of tag status (positive/negative), questions answered (yes/no), tag strength, and any associated notes.
* These classifications are clearly marked as coming from **Curate**.
**Updating ACMG data from Analyze**
While reviewing a variant in **Analyze**, you have multiple options to interact with **Curate** through [**Curate actions**](/emedgene/emedgene-analyze-manual/variant_page/curate-actions-in-analyze.md)**.**
Depending on whether the variant exists in **Curate** and your user permissions, the **Curate** button offers:
* **Add to Curate**: For new variants not yet in **Curate**
* **Update in Curate**: For existing variants. Updates include:
* Pathogenicity classification
* Variant interpretation
* Associated gene-disease connection (unless custom)
* Selected transcript (unless custom)
* ACMG classification details (tags, score, strength, and notes)
* **Open in Curate**: To view the stored **Curate** entry (available in previous versions as well).
This functionality ensures variant data stays synchronized across **Curate** and **Analyze** without manual duplication.
**ACMG schema version warnings**
When working in **Curate**, Emedgene keeps track of the ACMG schema version used for each curated SNV. If the variant was curated using an older schema than the one currently active in **Analyze**, you’ll see a **warning** in the **ACMG Classification card**.
Using an outdated schema may mean your classification is missing updated logic, revised strength definitions, or newly excluded tags.
#### Enhanced activity logging
To improve traceability:
* Any update to a **Curate** entry via **Analyze** is reflected in the **Activity Log**, capturing the full history of changes.
* Changes related to ACMG classification are grouped under a dedicated **Curate ACMG** category.
***
### Related Cases card
that shows, for every case within your organization containing the tagged variant of interest:
* Case name and genomic reference
* CNVs: Variant details (genomic coordinates and size)
* CNVs: Dynamic [annotation overlap](/emedgene/emedgene-analyze-manual/variant_page/related_cases_section/cnv_overlap_percentage.md) percentage filter
* CNVs: [Annotation overlap](/emedgene/emedgene-analyze-manual/variant_page/related_cases_section/cnv_overlap_percentage.md)
* Previously assigned [pathogenicity](/emedgene/emedgene-analyze-manual/variant_page/evidence_section.md)
* Case creation date
* Previously assigned variant [tag](/emedgene/emedgene-analyze-manual/variant_page/variant_tagging_widget.md)
* Variant inheritance
* Link to the case
For CNVs, all overlapping variants are displayed in the table. The minimal annotation overlap percentage filter is initially set to 70%, but it can be adjusted manually (1-100%).
***
### Network Summary card
that shows, for each occurrence of the variant in each **Curate** database maintained by collaborators within your [**Network**](/emedgene/emedgene-analyze-manual/settings/network.md)**:**
* Collaborator
* CNVs: Variant details (genomic coordinates and size)
* CNVs: Dynamic [annotation overlap](/emedgene/emedgene-analyze-manual/variant_page/related_cases_section/cnv_overlap_percentage.md) percentage filter
* CNVs: [Annotation overlap](/emedgene/emedgene-analyze-manual/variant_page/related_cases_section/cnv_overlap_percentage.md)
* [Pathogenicity](/emedgene/emedgene-analyze-manual/variant_page/evidence_section.md)
* Case creation date
* SNVs: Transcript
* Gene-related disease
* Variant Interpretation in the dropdown
For CNVs, all overlapping variants are displayed in the table. The minimal annotation overlap percentage filter is initially set to 70%, but it can be adjusted manually (1-100%).
Variants displayed in your **Curate Variants table**, which only have a **Network Summary** tab on the **Variant page**, are previewed from your collaborator(s)' **Curate** database(s) and are not part of your **Curate** database. To add such a variant to your Curate, click the **Import** button. Once added, you're free to edit **Pathogenicity**, **Interpretation notes**, **Gene's Related Diseases**, and **Variant Transcript** to your preference.
***
### Activities panel
The **Activities panel** records a history of user activities on the **Curate Variant page**. Click the **Activities** button to open it.
***
### Maximize button
The arrow icon on the top left of the **Curate Variant page** is a button that switches the view mode between:
* **Curate Variant table** is hidden, while the **Curate Variant page** is maximized
* **Curate Variant table** is shown, while the **Curate Variant page** is reduced
---
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