# Curate Gene page
### **The Top bar lists:**
* Gene symbol
* DNA strand orientation
* Gene type
* Clickable HGNC ID (links to HGNC)
* Clickable NCBI ID (links to NCBI Gene)
### The Gene Information card features:
* Official full gene name approved by the HGNC
* Alias symbols
* Location relative to GRCh37 and GRCh38 (with links to UCSC Genome Browser)
* Gene type
* Gene family
### **The Interpretation card features:**
* The Curated tab to be used for your curated gene interpretation. This text can be reused in the [Variant Interpretation notes](https://help.connected.illumina.com/emedgene/emedgene-analyze-manual/variant_page/evidence_section) or Gene interpretation notes within a case
* The Note tab for your draft notes on the gene
{% hint style="info" %}
**Note:** to edit your notes, select the tab (Curated or Note), and press the Edit button. Edit the text and apply the formatting. Don't forget to click Save!
{% endhint %}
### **The Transcript card includes:**
* Canonical transcript
* Exon count
* Organization preferred transcript
* A dropdown list featuring all known transcripts. This is where you can select a preferred transcript to be used in case analysis instead of the default one. The organization's preferred transcript is indicated by a star icon, while the canonical transcript is marked by a checkmark icon
* A Copy button to conveniently copy transcript details to your clipboard
### **The Gene Metrics card displays gene metrics from ExAC, gnomAD and ClinGen that assess the potential pathogenic impact of gene alterations:**
* RVIS - Residual variation intolerance score
* p(LoF intolerant) - Probability of loss of function intolerance
* p(REC) - Probability of being intolerant to homozygous, but not heterozygous LoF variants
* O/E score - Ratio of the observed/expected number of LoF variants
* HI - Haploinsufficiency
* TS - Triplosensitivity
* Z missense - Intolerance to missense variants based on the deviation of observed missense variants versus the expected number
### **The Variants summary card features:**
* A percent bar that illustrates trends in previous Pathogenicity classification
* A table summarizing Pathogenicity and severity across variants in the gene that have been previously added to Curate in a table view
* A link to See Related Variants
### **The RefSeq Summary card showcases:**
* Gene summary sourced from RefSeq
* A link to the respective NCBI Gene page
* A convenient Copy button for quick data retrieval
### **The Gene's related diseases card includes:**
* The number of gene-associated diseases sourced from OMIM, ORPHANET, CGD, ClinVar, and academic papers incorporated in Emedgene knowledge graph
* The list of Gene's Related Diseases with links to data sources
* Icons representing inheritance modes, when available
* An expandable condition summary from Uniprot (accessible via dropdown) along with a link to Uniprot and a copy button for convenient data extraction
### **Activities panel**
The Activities panel records a history of user activities on the Curate Variant page. Click on the Activities button to open it.
